某市东部沿海地区糖调节受损人群生化指标变化及危险因素分析

目的 观察分析某市东部沿海地区糖调节受损(IGR)人群血液生化指标和体格特征的变化,探讨影响IGR发生的危险因素.方法 按世界卫生组织糖尿病专家委员会1999年诊断标准,将IGR人群分为I-IFG、I-IGT和IGT/IFG三个类型组,并与正常糖耐量组(NGT)进行比较,然后运用单因素和多因素非条件Logistic回归分析影响IGR发生的危险因素.结果 ① IGR三个类型组与NGT组比较,其年龄、血压、BMI、WHR、FPG、2 hPG、TC、TG、LDL-C、UA、FINS、HOMA-IR水平均较高,HDL-C水平较低,差异具有统计学意义(P<0.05或P<0.01).IFG/IGT组与I-IFG、I-IGT两组比较,其FPG、2 hPG、HbA1c、TC、TG、LDL-C、UA、FINS、HOMA-IR水平均较高,HDL-C水平较低,差异具有统计学意义(P<0.05).②进入多因素非条件Logistic回归模型的因素有年龄、血压、BMI、WHR、TC、TG、LDL-C、低HDL-C、UA及糖尿病家族史(P<0.05或P<0.01).结论 ①IGR人群不同程度存在着血糖、血脂代谢异常和胰岛素抵抗,检测血糖、血脂及胰岛素等生化指标,对于评价IGR有一定的作用.②年龄增长、中心性肥胖、高血压、血脂紊乱、高尿酸血症及糖尿病家族史为IRG的主要危险因素.

Changes of biochemical parameters and risk factors analysis in patients with impaired glucose regulation in the eastern coastal areas of certain city

Objective To explore the changes of blood biochemical parameters and physical characteristics in patients with impaired glucose regulation(IGR) in the eastern coastal areas of certain city and to investigate the influence of IGR risk factors.Methods According to World Health Organization diabetes experts committee diagnostic criteria in 1999,IGR population were divided into three types,including I-IFG,I-IGT and IGT/IFG,which were compared with normal glucose tolerance(NGT) group.Single factor and multiple factors regression analysis were performed to logistically explore the IGR risk factors.Results ①Compared with NGT group,the three types of IGR group were with higher level of age,blood pressure,BMI,WHR,FPG,2 hPG,TC,TG,LDL-C,UA,FINS and HOMA-IR level,but with lower level of HDL-C(P<0.05 or P<0.01).Compared with I-IFG group and I-IGT group,IFG/IGT group were with higher level of FPG,2 hPG,HbA1c,TC,TG,LDL-C,UA,FINS and HOMA-IR,but with lower level of HDL-C(P<0.05).②Factors,included in multivariate conditional logistic regression model,were age,blood pressure,BMI,WHR,TC,TG,LDL-C,low HDL-C,UA and family history of diabetes mellitus(P<0.05 or P<0.01).Conclusion ①Subjects with IGR might be with different degree of abnormal metabolism of blood glucose and lipid and insulin resistance.Detection of blood sugar,lipids,insulin and other biochemical indexes could be helpful for the evaluation of IGR.②Age,central obesity,hypertension,dyslipidemia,hyperuricemia and family history of diabetes might be the main risk factors of IRG.