性早熟女童血清ghrelin水平研究

目的 探讨性早熟女童血清ghrelin水平变化.方法 将87例5～9 岁性早熟女童根据第二性征发育情况、骨龄、子宫、卵巢容积及促性腺激素释放激素(GnRH)激发试验的结果分为特发性中枢性早熟(ICPP)组和单纯乳房早发育(PT)组,选择34例年龄相当的健康女童作为对照组,采用夹心法酶联免疫吸附试验测定空腹血清ghrelin水平.结果 ICPP组血清ghrelin水平为Log(2.728±0.304)ng/L,明显高于对照组Log(2.567±0.304)ng/L],差异有统计学意义(P<0.05);PT组血清ghrelin水平为Log(2.613±0.300)ng/L,与ICPP组和对照组比较,差异均无统计学意义(P>0.05).结论 ICPP组血清ghrelin水平明显高于对照组,推测ICPP女童血清ghrelin变化可能与性激素升高有关.

Study of serum ghrelin level in girls with precocious puberty*

Objective To investigate serum ghrelin level in girls with precocious puberty.Methods 87 cases of girls,aged from 5 to 9 years,with precocious puberty were enrolled and divided into idiopathic central precocious puberty(ICPP) group and premature thelarche(PT) group according to secondary sexual characteristics,bone age,volumes of uterus and ovary and results of GnRH test,and 34 cases of age-matched healthy girls were enrolled as control group.Serum ghrelin level was measured by sandwich enzyme-linked immunosorbent assay in all groups.Results Serum ghrelin level in ICPP group was(2.728±0.304)ng/L,which was significantly higher than that of(2.567±0.304)ng/L in control group(P<0.05).Serum ghrelin level in PT group was(2.613±0.300)ng/L,which was not statistically different with those in ICPP group and control group(P>0.05).Conclusion Serum ghrelin level in ICPP group might be higher than that in control group,but that in PT group might be not significantly different with those in ICPP group and control group.