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缺血修饰清蛋白检测在急性冠状动脉综合征中的临床应用
引用本文:牛广华,高玉洁,王柏山,柴伟,彭程,张婷婷,张艺凡,索德宝.缺血修饰清蛋白检测在急性冠状动脉综合征中的临床应用[J].国际检验医学杂志,2013,34(24):3303-3304,3307.
作者姓名:牛广华  高玉洁  王柏山  柴伟  彭程  张婷婷  张艺凡  索德宝
作者单位:牛广华 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 高玉洁 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 王柏山 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 柴伟 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 彭程 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 张婷婷 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 张艺凡 (辽宁省中医药大学附属医院,辽宁沈阳,110032); 索德宝 (辽宁省中医药大学附属医院,辽宁沈阳,110032);
基金项目:国家高技术研究发展计划(863计划),资助项目(项目编号:2011AA02A1111)
摘    要:目的 探讨急性冠状动脉综合征(ACS)患者血清缺血修饰清蛋白(IMA)及心肌损伤标志物的变化和临床应用价值.方法 对确诊的126例ACS患者和48例健康对照组进行IMA、肌钙蛋白I(cTnI)、肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)、C反应蛋白(CRP)、心电图(ECG)、冠脉造影(CAC)检测,并进行统计分析.结果除SA组以外,其余ACS患者的IMA与健康对照组比较,差异均有统计学意义(P〈0.01).ECG与IMA、cTnI、Mb、CK-MB、CRP诊断SA、UA、AMI的敏感性比较:IMA〉Mb〉cTnI〉ECG〉CRP〉CK-MB,IMA在各组中敏感性均最高,在AMI组可达97.62%.ECG与IMA、cTnI、Mb、CK-MB、CRP诊断SA、UA、AMI的特异性比较:IMA〉cTnI〉Mb〉ECG〉CRP〉CK-MB,AMI组IMA特异性最高可达100.0%.结论 IMA与其他检测指标相比,能及时提示急性心肌缺血的发生,具有出现时间早、敏感性高、阴性预测值高等优点,是一种较理想的早期诊断心肌缺血的指标.

关 键 词:缺血修饰清蛋白  心肌损伤标志物  急性冠状动脉综合征

The clinical application of ischemia modified albumin detection in acute coronary syndrome
Niu Guanghua,Gao Yujie,Wang Baishan,Chai wei,Peng Cheng,Zhang Tingting,Zhang Yi fan,Suo Debao.The clinical application of ischemia modified albumin detection in acute coronary syndrome[J].International Journal of Laboratory Medicine,2013,34(24):3303-3304,3307.
Authors:Niu Guanghua  Gao Yujie  Wang Baishan  Chai wei  Peng Cheng  Zhang Tingting  Zhang Yi fan  Suo Debao
Institution:(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang ,Liaoning 110032,China)
Abstract:Objective To investigate the changes and the clinical application of ischemia-medified albumin(IMA) for patients with acute coronary syndrome(ACS) and the myocardial injury markers. Methods The levels of IMA,cardiac troponin I(cTnI), myohemoglobin(Mb) ,creatine kinase isoenzyme(CK-MB), C-reactive protein(CRP), electrocardiogram(ECG) ,and coronary angi- ography(CAC) were determined in 126 patients who were diagnosed ACS and 48 healthy people who were enrolled as control group,and the data were analyzed statistically. Results The serum levels of IMA test in patients with ACS were higher than those in healthy controls(P〈0.01 ), except SA group. The diagnosis sensitivity of ECG. IMA. cTnI. Mb. CK-Mb and CRP in SA, UA, AMI group from highest to lowest were.. IMA, Mb, cTnI, ECG, CRP, CK-MB, respectively. The sensitivity of IMA was the highest, which was even up to 97.2 % in AMI group. The diagnosis specificity of ECG, IMA, cTnI, Mb, CK-Mb and CRP in SA, UA, AMI group from highest to lowest were:IMA, cTnI, Mb, ECG,CRP, and CK-MB. The specificity of IMA in AMI group was the highest, which was up to 100.0%. Conclusion Compared with other markers, IMA is an early sensitive marker to the diagnosis of ACS, which has high negative predictive value.
Keywords:ischemia modified albumin  myocardial injure marker  acute coronary syndrome
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