苏州地区门诊男性患者高危型人乳头瘤病毒基因型分析

目的了解苏州地区门诊男性患者高危型人乳头瘤病毒(HR-HPV)的感染状况、基因型分布,以及与疾病的相关性。方法运用多重聚合酶链式反应和流式荧光杂交技术对1 432例门诊男性患者进行HR-HPV分型检测。结果 HR-HPV总感染率为25.63%,单一感染、双重感染和多重感染分别占72.20%、21.25%和0.65%,不同年龄段人群HR-HPV感染率比较,差异无统计学意义(χ~2=1.912,P=0.861)。位于前5位的HR-HPV亚型分别为HPV-16、HPV-52、HPV-58、HPV-18及HPV-59,HPV-16、HPV-52、HPV-58感染最常见于20岁、60岁及20岁人群,与HR-HPV相关的前3位疾病为病毒疣、尿道炎及龟头炎。结论 HPV-16是本地区男性患者最常见的HR-HPV感染型别,其次是HPV-52、HPV-58,HR-HPV感染具有一定年龄特异性,与男性病毒疣、尿道炎及龟头炎等疾病有关。

Analysis on high risk human papillomavirus genotypes among male outpatients in Suzhou area

Objective To understand the infection status ,genotype distribution of high risk human papillomavirus (HR-HPV ) infection and its relation with diseases among male outpatients in Suzhou area .Methods The HR-HPV DNA genotyping detection in 1432 male outpatients was performed by using multiple polymerase chain reaction and flow cytometry fluorescence hybridization technique .Results The total infection rate of HR-HPV was 25 .6% (367/1432) ,single infection ,double infection and multiple infection accounted for 72 .20% ,21 .25% and 0 .65% respectively .The HR-HPV infection rate had no statistical difference among different age groups(χ2 =1 .912 ,P=0 .861) .The top five places of HR-HPV subtypes were HPV-16 ,HPV-52 ,HPV-58 ,HPV-18 and HPV-59 .HPV-16 ,HPV-52 ,HPV-58 infections were most common among the age groups of ＜20 years old ,＞ 60 years old and ＜20 years old ,and the top 3 diseases related to HR-HPV were verruca ,urethritis and balanitis .Conclusion HPV-16 is the most common HR-HPV infection type in male outpatients ,followed by HPV-52 and-58 .The HR-HPV infection has a certain age specificity and is related to male verruca ,urethritis and balanitis .