| 血清6-磷酸葡萄糖异构酶及抗CCP抗体等联合检测对类风湿关节炎临床诊断应用的研究 |
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| 引用本文： | 苏娜,窦存瑞,谭榜云,韩建平,李燕平.血清6-磷酸葡萄糖异构酶及抗CCP抗体等联合检测对类风湿关节炎临床诊断应用的研究[J].国际检验医学杂志,2009,30(10):971-973. |
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| 作者姓名： | 苏娜 窦存瑞 谭榜云 韩建平 李燕平 |
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| 作者单位： | 1. 兰州大学第一医院检验科,730000
2. 兰州大学第一医院风湿科,730000 |
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| 摘 要： | 目的探讨葡萄糖6-磷酸-异构酶（GPI）在类风湿关节炎（RA）患者诊断中的意义。方法用双抗体夹心酶联免疫吸附试验（ELISA）法检测69例类风湿关节炎（RA）患者，29例其他风湿患者、40例健康对照血清中GPI浓度，同时检测RA患者类风湿因子（RF）、环瓜氨酸肽（CCP）抗体、血沉等血液指标。结果RA患者中GPI浓度为2．41±2．27，其他风湿患者为0．18±0．13，健康对照组为0．11±0．05。GPI浓度在类风湿关节炎患者血清中显著高于其他风湿病组和健康对照组（P〈0．05）。结论部分RA患者血清GPI浓度显著增高，GPI可以作为临床诊断RA的指标之一，同时可作为病情活动状况的判断依据。
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| 关 键 词： | 葡糖6-磷酸异构酶 关节炎，类风湿 抗体 |
Diagnostic value of combinate determination of serum glucose-6 phosphate isomerase and anti-CCP antibody for rheumatoid arthritis |
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| Abstract: | Objective To explore the clinical value of glucose-6 phosphate isomeras(GPI)in diagnosis of rheumatoid arthritis(RA).Methods Serum level of GPI was measured with enzyme linked immunosorbent assay(ELISA)in 69 cases of RA(RA group),29 cases of non-RA rheumatic diseases(non-RA group)and 40 cases of healthy controls(healthy control group).Simultaneously,rheumatoid factor(RF),anti-cyelic citrulinated pepetide antibody(anti-CCP)and erythrocyte sedimentation rate (ESR)were measured in RA patients.Results Serum level of GPI was significantly higher in RA group(2.41±2.27)than that in non-RA group(0.18±0.13)and healthy control group(0.11 ±0.05)(P＜0.05).Conclusion Serum level of GPI is significantly increased in some RA patients.Therefore,GPI may be used as a marker for clinical diagnosis and activity of pathogenetic condition of RA. |
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| Keywords: | Glucose-6-Phosphate Isomerase Arthritis Rheumatoid Antibodies |
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