应用高频超声评价辛伐他汀对动脉粥样硬化血管内皮功能的影响

目的：应用高频超声评价辛伐他汀对动脉粥样硬化（AS）兔血管内皮功能的影响。方法：50只兔随机分为3组：A组为对照组（5只）；B组为AS模型组（25只）；C组为辛伐他汀治疗组（20只）。超声检测不同时期各组兔的血管内皮依赖性舒张功能（EDD）和血管内皮非依赖性舒张功能（NEDD），并进行了相关的血脂测定及病理检查。结果：辛伐他汀治疗组兔的血脂水平明显减低，EDD较AS组明显改善，12周以后NEDD较AS组有显著差异。结论：辛伐他汀可以保护血管内皮功能，减轻AS病变程度。高频超声是评价药物对血管内皮功能影响的良好方法。

Evaluation the effect of simvastatin on vascular endothelial function by high frequency sonography in atherosclerotic rabbits

Objective：To assess the effect of simvastatin on vascular endothelial function by high frequency sonography.Methods：Fifty rabbits were randomly divided into control group（A group） and atherosclerotic group（B group） and simvastatin group（C group）.Endothelial dependent dilation（EDD） and non-endothelial dependent dilation（NEDD） were measured with high resolution sonography at different time.Results：After intervention of simvastatin,the blood lipid decreased,EDD function was obviously improved,and NEDD was improved after 12 weeks.There was significant difference between the two groups.Con-clusions：Simvastatin can improve endothelial function.High frequency sonography can be used to assess the effect of drug therapy on endothelial function.