国产钆喷酸葡胺联合LAVA动态增强扫描在肝脏病变中的应用

目的：探讨国产钆喷酸葡胺（ Gd-DTPA ）联合 MRI 三维肝脏容积加速采集技术（ LAVA）动态增强扫描在肝脏疾病中的应用价值。方法529例肝脏占位性病变患者采用国产Gd-DTPA联合LAVA检测病灶，分析此方法的准确性及强化效果。结果529例经病理学检查确诊肝癌317例、转移瘤107例、血管瘤50例、胆管细胞癌38例、肝脏局灶性结节增生17例。国产Gd-DTPA联合MRI LAVA动态增强扫描检测结果与病理学检查结果的符合率达98.7％（522/529）。正常组织及病变组织出现强化效果者占100％、99.4％。肝癌以显著强化（74.2％）、不均匀强化（73.2％）为主；转移瘤以轻度强化（81.8％）、边缘强化（41.8％）为主；血管瘤以显著强化（76.0％）、边缘强化（46.0％）为主；胆管细胞癌以轻度强化（62.5％）、边缘强化（52.5％）为主；肝局灶性结节增生以显著强化（89.5％）、均匀强化（73.7％）为主。结论国产Gd-DTPA联合MRI LAVA动态增强扫描对腹部各器官增强效果理想，有助于诊断肝脏病变性质。

Domestic Gd-DTPA combined with LAVA dynamic contrast-enhanced MRI scanning application in liver disease

Objective To explore the application value of domestic gadopentetate dimeglumine （Gd-DTPA） combined with liver acquisition with volume acceleration （ LAVA） dynamic contrast-enhanced MRI scanning in liver disease.Methods Five hundred and twenty-nine patients of liver space-occupying le-sion received domestic Gd-DTPA combined with LAVA dynamic contrast-enhanced MRI scanning , analyzed the accuracy of this method and strengthening effect.Results Confirmed by pathological examination , 317 cases of liver cancer , 107 cases of metastatic tumor , 50 cases of hemangioma , 38 cases of cholangiocellular carcino-ma and 17 cases of hepatic focal nodular hyperplasia were diagnosed.Diagnose accordance rate of domestic Gd-DTPA combined with LAVA dynamic contrast-enhanced MRI scanning was 98.7%.Normanl tissue and dis-eased tissue appear strengthening effect accounted for 100%and 99.4%, respectively.Liver cancer was given priority to be significantly strengthened （74.2%） and uneven enhancement （73.2%）;metastatic tumor was given priority to be slightly strengthened （81.8%） and edge enhancement （41.8%）;hemangioma was given priority to significantly strengthened （76.0%） and edge enhancement （46.0%）; cholangiocellular carcino-ma was given priority to be slightly strengthened （ 62.5%） and edge enhancement （ 52.5%）; hepatic focal nodular hyperplasia was given priority to be slightly strengthened （89.5%） and even enhancement （73.7%）.Conclusion Domestic Gd-DTPA combined with LAVA dynamic contrast-enhanced MRI scanning has a good strengthening effect to help diagnose liver diseases.