支气管扩张症患者维生素D缺乏与慢性鼻窦炎的相关性研究

目的 探讨支气管扩张症（支扩）患者维生素D缺乏与慢性鼻窦炎的关系。方法 选择119例支扩患者,检测其入院时血清25-羟维生素D25（OH）D]、血清总IgE、嗜酸性粒细胞比例,并对其进行鼻窦CT Lund-Mackay评分。根据患者入院时血清25（OH）D是否<20 ng/mL分为维生素D缺乏组和正常组,比较支扩患者中维生素D缺乏组与正常组间的慢性鼻窦炎发生率,以及支扩合并鼻窦炎患者中维生素D缺乏组与正常组的Lund-Mackay评分,分析支扩合并鼻窦炎患者血清25（OH）D水平及与Lund-Mackay评分的相关性。结果 119例支扩患者中,69例存在维生素D缺乏,50例维生素D正常;其中有鼻窦炎的患者71例,占59.7%,48例患者鼻窦无异常;与维生素D正常组相比,维生素D缺乏组的慢性鼻窦炎发生率更高（P < 0.05）。71例支扩合并慢性鼻窦炎的患者中,维生素D缺乏组的Lund-Mackay评分高于维生素D正常组（P < 0.05）。支扩合并慢性鼻窦炎患者的血清25（OH）D水平与Lund-Mackay评分呈负相关（P < 0.05）。 结论 支扩患者的维生素D缺乏与其慢性鼻窦炎发生、发展有关。

Study of the correlation between vitamin D deficiency and chronic sinusitis in patients with bronchiectasis

Objective To investigate the relationship between vitamin D deficiency and chronic sinusitis in patients with bronchiectasis. Methods A total of 119 patients with bronchiectasis were selected. Upon admission, serum 25-hydroxyvitamin D （25（OH）D）, serum total IgE and the proportion of eosinophil were detected, and sinus CT scan （Lund-Mackay score） was performed. According to whether the serum 25（OH）D level was less than 20 ng/mL, all patients were divided into the vitamin D deficiency group （< 20 ng/mL） and normal group （≥20 ng/mL）. The incidence of chronic sinusitis in patients with bronchiectasis was statistically compared between two groups. Lund-Mackay score in bronchiectasis patients complicated with sinusitis was compared between two groups. Moreover, the correlation between serum 25（OH）D level and Lund-Mackay score in bronchiectasis patients complicated with sinusitis was analyzed. Results Among 119 patients with bronchiectasis, 69 cases developed vitamin D deficiency and 50 had normal vitamin D levels; 71 of them were complicated with sinusitis, accounting for 59.7%, and 48 patients had no sinus abnormality. Compared with the normal group, the incidence of chronic sinusitis were significantly higher in the vitamin D deficiency group （both P < 0.05）. Among 71 bronchiectasis patients complicated with chronic sinusitis, Lund-Mackay score in the vitamin D deficiency group was considerably higher than that in the normal group （P < 0.05）. In bronchiectasis patients complicated with chronic sinusitis, serum 25（OH）D level was negatively correlated with Lund-Mackay score （P < 0.05）. Conclusion In bronchiectasis patients, vitamin D deficiency is correlated with the incidence and progression of chronic sinusitis.