支气管扩张症患者中肺曲霉病的研究进展

支气管扩张症（支扩）是多种病因导致的一支或多支的近端支气管不可逆性扩张（支气管直径>2 mm）的气道慢性炎症性疾病。其多数是由感染引起,而感染又能诱发支扩,两者互为因果。支扩患者感染的病原体大多为细菌,且已得到充分研究证实,而曲霉在支扩患者中定植比较少见,发病机制尚不明确,但是近年来肺曲霉病发生率呈上升趋势,尤其是在支扩伴感染的患者中更为常见。另外支扩患者中维生素D水平已被证实与其严重程度呈负相关,但相关研究文献较少。该文对支扩与肺曲霉病的相关方面及诊治进行探讨,旨在为相关研究提供理论支撑。

Research progress on pulmonary aspergillosis in patients with bronchiectasis

Bronchiectasis is a chronic inflammatory disease of the airway in which one or more proximal bronchi （diameter greater than 2 mm） are irreversibly dilated caused by a variety of causes. Bronchiectasis is mainly caused by infection, and infection can induce bronchiectasis instead, which exert mutual effect. Bacteria have been proven as the major pathogens of infection by multiple studies. Aspergillus colonization is relatively rare in patients with bronchiectasis, whereas the pathogenesis remains elusive. Nevertheless, the incidence of pulmonary aspergillosis has been on the rise in recent years, especially in bronchiectasis patients complicated with infection. In addition, vitamin D level in bronchiectasis patients has been confirmed to be negatively correlated with the severity. However, relevant studies have seldom been reported. In this article, the relationship of bronchiectasis and pulmonary aspergillosis, their diagnosis and treatment were investigated, aiming to provide theoretical evidence for relevant research.