Hypoglycemic efficacy and safety of Momordica charantia (bitter melon) in patients with type 2 diabetes mellitus |
| |
| Institution: | 1. Department of Internal Medicine, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea;2. Institute of Health Sciences, Gyeongsang National University Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea;3. Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Gyeongsang National University School of Medicine, Jinju, Republic of Korea;4. Department of Anatomy and Neurobiology, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju, 52727, Gyeongnam, Republic of Korea;1. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China;2. College of Yingdong Food Science and Engineering, Shaoguan University, Shaoguan 512005, China;3. College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China;4. School of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing 210023, China;1. Department of Orthopedic, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia;2. Central Research Laboratory, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia;3. Department of Family Medicine, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia;4. Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, Kubang Kerian, Kelantan, Malaysia;1. Department of Agricultural and Environmental Sciences, Tennessee State University, Nashville, TN, USA;2. Department of Biological Sciences, Tennessee State University, Nashville, TN, USA;3. College of Food Science and Technology, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China;1. Department of Molecular and Integrative Physiology, The University of Kansas Medical Center, Kansas City, KS 66160, USA;2. Department of Surgery, The University of Kansas Medical Center, Kansas City, KS 66160, USA;3. The University of Kansas Cancer Center, Kansas City, KS 66160, USA;4. Interdisciplinary Science & Technology Research Academy, Abeda Inamdar Senior College, Azam Campus, Pune, 411001, India |
| |
| Abstract: | IntroductionMomordica charantia (bitter melon) is widely used for its glucose-lowering effects. This study was conducted to assess the efficacy and safety of M. charantia as an adjuvant treatment in patients with type 2 diabetes.MethodsWe performed a randomized, placebo-controlled study. Blood glucose levels, lipid profile, and adverse events were investigated after 12 weeks of treatment. Ninety subjects were included in the final analysis for glucose lowering efficacy of bitter melon.ResultsThere were no differences in age, sex, or glycated hemoglobin (HbA1c) levels between the bitter melon extract and placebo groups. After treatment with bitter melon extract for 12 weeks, the HbA1c levels of the bitter melon and placebo groups remained unchanged; however, the average fasting glucose level of the bitter melon group decreased (p = 0.014). No serious adverse events were reported during the treatment period.ConclusionsOur data showed that bitter melon has effects of glucose lowering in patients with type 2 diabetes. |
| |
| Keywords: | Adjuvant therapy Hypoglycemic agents Type 2 diabetes mellitus |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
