复方丹参注射液对急性心肌梗死溶栓治疗再灌注损伤防治作用的研究

目的 :探讨急性心肌梗死 (AMI)再灌注损伤的有效中西医结合防治方法。方法 :选择具有溶栓指征的AMI患者 12 6例 ,配对分为治疗组与对照组 (各 6 3例 ) ,两组均行尿激酶静脉溶栓治疗。治疗组在使用尿激酶前 10～ 30 min或同时加用复方丹参注射液 2 5 0 m l,每日 1次 ,连用 7d。对照组仅用尿激酶及常规治疗。结果 :治疗组与对照组再通分别为 4 8例 (76 .19% )和 4 0例 (6 3.4 9% ) ;住院期间死亡分别为 2例 (3.17% )和 8例(12 .6 9% ) ;发生严重心力衰竭分别为 2例 (3.17% )和 8例 (12 .6 9% ) ;发生再灌注心律失常分别为 16例(2 5 .39% )和 33例 (5 2 .38% )。两组比较差异均显著 (P<0 .0 5或 P<0 .0 1)。同时 ,治疗组在减少心肌耗氧量、缩小梗死面积、减少心肌酶释放、提高左室射血功能及减轻疼痛等方面都显著优于对照组 (P均 <0 .0 5 )。结论 :复方丹参注射液具有抗 AMI再灌注损伤的作用 ,可减少心肌耗氧量 ,减少心肌酶的释放 ,缩小心肌梗死面积和左心室射血功能

Prevention and treatment effect of composite salvia miltiorrhiza injection(复方丹参注射液) on acute myocardial infarction patients with reperfusion injury by thrombolytic cure

Objective: To explore the prevention and treatment of acute myocardial infarction(AMI) with reperfusion injury. Methods: One hundred and twenty-six AMI patients with signs of thrombolysis were randomly divided into two groups. The therapeutic group and the control group( n =63 for each group). Both groups were given thrombolytic therapy with urokinase intraveously. The therapeutic group was given composite salvia miltiorrhiza injection 250 ml 10-30 minutes before giving urokinase or at the same time, once a day and lasted seven days. The control group was only given urokinase and routine treatment . Results: In therapeutic group and the control group, 48(76 19 percent) and 40 (63 49 percent) patients repassed, 2(3 17 percent) and 8(12 69 percent) patients died in hospital, 2(3 17 percent)and 8 (12 69 percent ) patients suffered from severe heart failure, 16 (25 39 percent) and 33 (52 38 percent) patients suffered from reperfusion arrhythmias, there were significant differences between two groups( P <0 05 or P <0 01 ). At the same time, the effects of therapeutic group were better than the control group in reducing myocardial consumption of oxyen, releasing cardiac infarction size, enhencing left ventricular stroke volume and other inspects (all P <0 05). Conclusion: Composite salvia miltiorrhiza injection have the function against reperfusion injury of AMI.