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加味炙甘草汤注射液治疗病态窦房结综合征的电生理研究
引用本文:陈元禄,黄体钢,王志毅.加味炙甘草汤注射液治疗病态窦房结综合征的电生理研究[J].中国中西医结合急救杂志,2000,7(2):78-81.
作者姓名:陈元禄  黄体钢  王志毅
作者单位:天津医科大学第二医院心脏科!天津300211(陈元禄,黄体钢),天津医科大学总医院!天津300052(王志毅,王希哲),天津市胸科医院!天津300051(梁爽林,张国琴),天津医科大学实验中心!天津300070(吴伊丽,曹煦)
基金项目:天津市卫生局科研项目!(95418)
摘    要:观察加味炙甘草汤注射液对窦房结功能损伤兔电生理的影响,探讨加味炙甘草汤注射液治疗病态窦房结综合征的临床疗效和机制。方法:应用经静脉和经食管心房调搏方法观察加味炙甘草汤注射液的窦房结电生理作用。结果:应用加味炙甘草汤注射液后,SND兔的窦房结恢复时间(SNRT)、校正SNRT(SNRTc)较对照组明显缩短,心脏固有心率(IHRo)明显上升,总窦房传导时间(TSACT)无改变。临床电生理结果与动物实验

关 键 词:炙甘草汤注射液  窦房结  电生理  病窦综合征

Electrophysiological effects of honeyed glycyrrhiza compound decoction injection on sick sinus syndrome
CHEN Yuanlu,HUANG Tigang,WANG Zhiyi,et al..Electrophysiological effects of honeyed glycyrrhiza compound decoction injection on sick sinus syndrome[J].Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2000,7(2):78-81.
Authors:CHEN Yuanlu  HUANG Tigang  WANG Zhiyi  
Institution:CHEN Yuanlu,HUANG Tigang,WANG Zhiyi,et al.Department of Cardiology,Second Hospital of Tianjin Medical University,Tianjin 300211
Abstract:ObjectiveTo observe the electrophysiological and clinical effects of honeyed glycyrrhiza compound decoction (HGCD) injection on sick sinus syndrome (SSS),and to explore their effect mechanism.MethodsObserving the electrophysiological changes of HGCD injection on SSS used intravenous and transesophageal atrial pacing.ResultsAfter intravenous HGCD injection on rabbits with experimental sinus node damage (SND),sinus node recovery time (SNRT) and corrected SNRT(SNRTc) shortened and intrinsic heart rate (IHRo) increased significantly in treatment group compared with those in control group (P<0.01 or P<0.05).Total sinoatrial conduction time (TSACT) was not difference between the two groups.Clinical electrophysiological changes was the same as those in animal study.After administration of HGCD injection,three parameters (SNRT,SNRTc and IHRo) were recovered into normal in 3 cases,two parameters(SNRT and SNRTc) were recovered in 1 case,and one parameter(SNRTc) was recovered in 1 cases.The effective rate of HGCD injection in treatment of SSS was 38.5(5/13).There was no significance of atrial effective refractory period (AERP) and atrial ventricular effective refractory period(AVERP) before and after treatment,and atrioventricular Wenckebachs block cycle length(AWBCL) significantly decreased after treatment(P<0.05).ConclusionsHGCD injection may improve sinus node automaticity in SND rabbits.HGCD is effective in treatment of SSS.Accelerating recovery of sinus node automaticity is the electrophysiological mechanism that HGCD injection treat SSS.
Keywords:sick sinus syndrome  honeyed glycyrrhiza compound decoction injection  sinus node  cardial electrophysiology
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