心乐宁浓缩液对心力衰竭犬血流动力学的影响

目的：观察心乐宁浓缩液对心力衰竭(心衰)犬血流动力学的影响。方法：实验动物随机分为阴性对照组(给生理盐水)，心衰模型组(给生理盐水)，心乐宁浓缩液小、中、大剂量组(经十二指肠给心乐宁浓缩液16、32、64g／kg)，以及阳性对照组(给地高辛77g／kg)。用电磁流量计探头放置到主动脉根部，测量心输出量；心导管经颈总动脉插入左心室记录左室内压，从股动脉测量动脉血压；并用公式计算其他血流动力学指标。结果:心乐宁浓缩液各剂量及地高辛均能轻度升高制模时降低的平均动脉压(P均＞0．05)，心乐宁浓缩液各剂量组增加心输出量的作用显著，地高辛组也能增加但不显著(P＞0．05)；心乐宁浓缩液各剂量组对心衰犬的左室内压有升高作用(P＜0．05和P＜0．01)，对左室作功指数也有显著的升高作用(P＜0．01)；地高辛组具有同等作用(P＜0．05或P＜0．01)。心乐宁大剂量组作用与地高辛组相当(P均＞0．05)。结论：心乐宁浓缩液能增加心衰时心输出量及左室作功指数，从而改善心功能。

Effect of Xinlening concentrates(心乐宁浓缩液) on hemodynamics in dog with heart failure

Objective: To investigate the influence of Xinlening concentrates on hemo dynamics in dogs with failure heart. Methods: The experimental dogs were randomly divided into six groups. Negative control group was infused with normal saline, heart failure group was infused with normal saline, different doses of Xinlening concentrates groups were given Xinlening concentrates 16 g/kg, 32 g/kg, and 64 g/kg respectively. Positive control group was treated with digoxin. The cardiac output was measured with the magnetic volumetric meter at the root of aorta. The inner pressure of left ventricle and the systemic artery pressure were measured by insertion of catheter into carotid and femoral artery respectively. Other hemodynamic indexes were also calculated by confirmed formula. Results: Different doses of Xinlening concentrates and digoxin could mildly increase the average artery pressures. The canine cardiac output could be improved dramatically by different dosage of Xinlening concentrate, the effect of increasing cardiac output of digoxin was not significant different( P >0 05). The inner pressure of left ventricle and the working indexes were also increased with the treatment of different doses of Xinlening concentrates, similar to that of digoxin( P <0 05). The effect of large dosage of Xinlening concentrate was similar to digoxin. Conclusion: The Xinlening concentrates may improve the cardiac output and left ventricular working indexes, improve the hemodynamic status of the canines with failure heart.