| 人体肠道微生物组与疾病研究:现状、机遇与挑战 |
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| 引用本文： | 方圆,潘元龙,朱宝利.人体肠道微生物组与疾病研究:现状、机遇与挑战[J].协和医学杂志,2022,13(5):713-718. |
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| 作者姓名： | 方圆 潘元龙 朱宝利 |
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| 作者单位： | 1.中国医学科学院北京协和医院基本外科，北京 100730 |
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| 基金项目： | 国家重点研发计划2021YFA1301000国家自然科学基金32170068济南微生态生物医学省实验室科研项目JNL-2022013B |
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| 摘 要： | 微生物组是人体的第二基因组，能够决定人的健康状态。微生物组研究促进了人类对微生物群体与人体、生态环境关系的新认识。对人体肠道微生物组的组成和功能进行系统研究，解析相关核心菌群的互作关系和调控机制，将为解决人类面临的健康问题带来革命性的理论创新，由此产生颠覆性的技术革新，有望为微生物组研究提供更好的解决方案。
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| 关 键 词： | 微生物组 肠道菌群 疾病 治疗 |
| 收稿时间： | 2022-05-24 |
Human Gut Microbiome and Diseases: Current Status,Opportunity and Challenges |
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| Institution: | 1.Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China2.Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China |
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| Abstract: | The human microbiome, the second genome of the human body, can determine human health status. Microbiome research has prompted humans to re-understand the relationship between microbiota and individuals, as well as microbiota and the ecological environment. A comprehensive and systematic study of the structure and function of human gut microbiome and an analysis of the interaction and regulation mechanism of the relevant core bacteria will bring revolutionary theoretical innovations to solve the health problems of humans, and the resulting disruptive technological innovation has the potential to provide better solutions for microbiome research. |
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