| 印记基因与小于胎龄儿研究进展 |
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| 引用本文： | 潘周娴,陈适,朱惠娟,龚凤英,潘慧.印记基因与小于胎龄儿研究进展[J].协和医学杂志,2020,11(2):186-190. |
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| 作者姓名： | 潘周娴 陈适 朱惠娟 龚凤英 潘慧 |
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| 作者单位： | 1.中国医学科学院 北京协和医学院 北京协和医院 变态反应科, 北京 100730 |
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| 基金项目： | 北京市卫生科技成果与适宜技术推广项目2018-TG-35 |
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| 摘 要： | 基因组印记是令一对等位基因仅表达父源或母源基因的一种表观遗传性修饰, 多在胎盘中存在, 对胎盘和胚胎发育至关重要。在对小于胎龄儿发病机制的研究中, 印记基因是不可缺少的一部分。但相关研究争议很大, 尚未得出统一的结论。本文就近些年印记基因与小于胎龄儿的研究予以综述。
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| 关 键 词： | 印记基因 小于胎龄儿 |
| 收稿时间： | 2017-05-31 |
Imprinted Genes and Being Small for Gestational Age |
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| Institution: | 1.Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China2.Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China3.Department of Medical Affairs, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China |
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| Abstract: | Imprinted genes are epigenetic modifications that make a pair of alleles express only paternal or maternal genes. Most of the imprinted genes exist in the placenta and are very important for placental and embryonic development. Imprinted genes are an indispensable part of the study of the pathogenesis of being small for gestational age. However, relevant research is controversial and has not yet reached a common conclusion. In this paper, recent studies on the relation ofimprinted genes and being small for gestational age are reviewed. |
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