稳定型心绞痛患者ApoB/ApoAI与左心室射血分数的相关性研究

目的探讨稳定型心绞痛患者载脂蛋白B(ApoB)/载脂蛋白AI(ApoAI)与左心室射血分数(LVEF)的关系。方法选取行冠状动脉造影后确诊为稳定型心绞痛的患者148例,根据ApoB/ApoAI的比值分为低危组(<0.8)98例和高危组(≥0.8)50例,行心脏彩超记录左心室射血分数(LVEF),以及记录其他临床指标检测值。结果高危组患者的血小板体积分布宽度(PDW)、LVEF水平低于低危组,D-二聚体(D-D)、低密度脂蛋白(LDL)水平高于低危组(P<0.05)。Spearman相关分析显示,LVEF与ApoB/ApoAI呈负相关(r=-0.280,P=0.003)。行受试者工作特征(ROC)曲线计算LVEF预测ApoB/ApoAI升高的曲线下面积(AUC)为0.644,在该研究人群中,当LVEF切点值取61.0%时,其预测ApoB/ApoAI升高的效能最高,灵敏度为58.1%,特异度为68.6%。结论在稳定型心绞痛患者中,ApoB/ApoAI与LVEF水平具有负相关性。

Study on correlation between ApoB/ApoAI and left ventricular ejection fraction in patients with stable angina pectoris

Objective To investigate the relationship between ApoB/ApoAI and the left ventricular ejection fraction(LVEF)in the patients with stable angina pectoris.Methods One hundred and forty-eight cases of stable angina definitely diagnosed by coronary angiography were selected and divided into the low-risk group(ApoB/ApoAI<0.8,98 cases)and high-risk group(ApoB/ApoAI≥0.8,50 cases)according to the ApoB/ApoAI ratio.The color echocardiography was performed to record LVEF and other clinical indicators also recorded.Results The platelet volume distribution width(PDW)and LVEF level in the high-risk group were lower than those in the low-risk group,while the levels of D-dimer(D-D)and low-density lipoprotein(LDL)were higher than those in the low-risk group(P<0.05).The Spearman correlation analysis showed that LVEF was negatively correlated with ApoB/ApoAI(r=-0.280,P=0.003).The receiver operating characteristic(ROC)curve was calculated using LVEF to predict the area under the curve(AUC)for ApoB/ApoAI elevation was 0.644.In this study population,when the LVEF initial value was 61.0%,it efficiency for predicting ApoB/ApoAI increase was the highest,with a sensitivity of 58.1% and a specificity of 68.6%.Conclusion In the patients with stable angina pectoris,ApoB/ApoAI has a negative correlation with the LVEF level.