荆门地区成年女性人乳头瘤病毒感染状况及基因分布

目的了解荆门地区成年女性人乳头瘤病毒(HPV)感染状况及基因型发布。方法采用聚合酶链反应-反向杂交法对276例宫颈细胞学检查异常的女性进行HPV基因检测及分型。结果共检出86例HPV阳性者,感染率为31.16%,HPV感染的主要类型为58、16、33型,<30岁组与40～55岁组高危亚型的感染率明显高于30～39岁组,为2个明显的高峰期,<30岁组低危亚型的感染率明显高于其他年龄组。结论荆门地区成年女性HPV感染状况与基因分布与国内其他地区存在一定的差异,在HPV感染的筛查中应关注2个年龄高峰段。

Status of HPV infection and its genotype distribution in adult females of Jingmen region

Objective To understand the situation of human papillomaviral （HPV） infection in adult females of Jingmen and genotype distribution. Methods PCR- reverse hybridization assay was used to detect HPV gene and genotype in 276 patients with abnormal cervical cytology. Results 86 cases were positive with HPV＇infection, with the infection rate of 31.16%. The primary HPV genotypes were HPV 58,16 and 33. The infection rates of under 29 years old group and 40 to 55 years old group at high risk were higher than that in 30 to 39 years old group. The in- fection rate in under 30 years old group with low-risk subtype infection was significantly higher than in other age groups. Conclusion The HPV infection situation and genotype distribution in Jingmen region might be different with other regions. The two age peak of HPV infection should be paid more attention for the screening of HPV infection.