子痫前期患者血浆晚期氧化蛋白产物与肾功能生化指标的相关性

目的：探讨子痫前期（PE）孕妇血浆中晚期氧化蛋白产物（AOPP）水平与 PE严重程度的相关性，同时分析AOPP水平对PE患者肾脏功能的影响。方法选取2009年4月至2013年4月南京市妇幼保健院收治的PE患者72例，分为轻度PE组（40例）和重度PE组（32例），同时选取入住本院的足月分娩的健康孕妇70例作为对照组。常规方法检测血浆中胱抑素C（CC）、尿酸（UA）、肌酐（Cr）和尿素氮（BUN）等肾功能指标，免疫比浊法检测24 h尿蛋白，分光光度计法检测AOPP ，并进行比较分析。结果重度 PE组患者的 AOPP水平明显高于轻度PE组和对照组孕妇，且轻度PE组患者的AOPP水平明显高于对照组孕妇，差异均有统计学意义（P＜0．05）；重度PE组的CC、UA、Cr和BUN水平明显高于对照组和轻度组，差异均有统计学意义（P＜0．05）；比较轻、重度PE组间24 h尿蛋白定量，差异有统计学意义（P＜0．05）；PE患者AOPP与24 h尿蛋白、CC明显相关，相关系数分别为0．682和0．601（P＜0．05）。结论 AOPP与24 h尿蛋白和CC明显相关性，可以推断PE患者体内AOPP水平对患者肾功能有一定影响。

Correlation between plasma level of advanced oxidation protein products and rental function in preeclampsia patients

Objective To investigate the correlation between plasma level of advanced oxidation protein prod‐ucts （AOPP） and severity of preeclampsia （PE） ,and to explore its effect on rental function .Methods A total of 72 cases of PE patients ,treated in this hospital from Apr .2009 to Apr .2012 were enrolled and divided into mild PE group （40 cases） and severe PE group （32 cases） .Another 70 cases of healthy pregnant women were selected as con‐trol group .Conventional method was used to detect the plasma levels of rental function related indexes ,including cys‐tatin C （CC） ,uricacid （UA） ,creatinine （Cr） and urea nitrogen （BUN） .24 h urinary protein level was detected by immunoturbidimetry method .AOPP level was determined by spectrophotometry .Results AOPP level of severe PE group was higher than mild PE group ,and that of the latter was higher than control group （P〈0 .05） .Levels of CC , UA ,Cr and BUN of severe PE group were higher than mild PE group and control group （P〈 0 .05） .Significant difference of 24 h urinary protein level could also be observed between mild and severe PE group （P〈0 .05） .AOPP level was significantly correlated with CC and 24 h urinary protein level ,with correlation coefficient of 0 .682 and 0 .601 ,respectively （P〈0 .05） .Conclusion AOPP level could be significantly correlated with CC and 24 h urinary protein level ,which might indicate that AOPP could be with influence on rental function in PE patients .