重庆地区853名健康女性血清人附睾蛋白4水平分布

目的：探讨重庆地区不同年龄段健康体检女性血清人附睾蛋白4（H E4）的水平分布，为验证本地区的女性血清H E4水平参考区间提供参考。方法选取2013年1～12月在重庆某三甲医院进行健康体检的健康女性853名，分为6组：20～29岁组、30～39岁组、40～49岁组、50～59岁组、60～69岁组、≥70岁组，检测、比较各年龄组H E4水平。结果20～29岁组、30～39岁组、40～49岁组、50～59岁组间H E4水平比较，差异无统计学意义（ P＞0．05）；将她们合并为＜60岁组后，与60～69岁组及≥70岁组比较，差异均有统计学意义（ P＜0．05）；以 x ±2s为参考上限，参考区间分别为：60岁以下 HE4＜60．83 pmol／L ，60～69岁 HE4＜84．51 pmol／L ，70岁及以上HE4＜93．79 pmol／L。结论重庆地区女性血清 HE4水平受年龄因素影响，建议按照60岁以下、60～69岁、70岁及以上分别建立女性血清 H E4水平的参考区间。

Investigation on distribution of the serum human epididymis protein 4 leveles in 853 healthy women in Chongqing

Objective To investigate the distribution of serum human epididymis protein 4（HE4） levels in healthy women of different age groups and areas of Chongqing ,and provide reference to evaluate the local reference range of serum HE4 level of healthy women in Chongqing .Methods A total of 853 healthy women ,conducted physi‐cal examination in a grade A hospital from Jan .to Dec .2013 ,were enrolled in this study and divided into 6 groups ,in‐cluding 20-29 years old group ,30 -39 years old group ,40 -49 years old group ,50 -59 years old group ,60 -69 years old group and ≥70 years old group .The serum HE4 levels were detected by chemiluminescence method and an‐alyzed among these age groups .Results There was no significant differences of serum HE4 levels among 20 -29 years old ,30-39 years old ,40-49 years old ,and 50-59 years old group（P〉0 .05） .However ,significant difference of serum HE4 levels was observed among 〈60 years old ,60-69 years old and ≥70 years old group（P〈0 .05） .U‐sing x±2s as reference range limits ,the reference range of serum HE4 in 〈 60 years old group ,60 -69 years old group and ≥70 years old group was 〈60 .83 pmol/L ,〈84 .51 pmol/L and 〈93 .79 pmol/L ,respectively .Conclusion Age could be an influencing factor of the serum HE4 level in women of Chongqing .The reference range of serum HE4 should be established separately for 〈60 years old group ,60 -69 years old group and ≥70 years old group .