血清补体C1q、RBP及尿mALB联合检测在儿童过敏性紫癜早期肾损伤中的临床意义

目的探讨血清补体C1q、视黄醇结合蛋白(RBP)及尿微量清蛋白(mALB)联合检测在儿童过敏性紫癜(HSP)早期肾损伤中的临床意义。方法选取该院2017年7月至2018年12月住院的70例HSP患儿作为观察组,其中单纯型HSP 50例,合并紫癜性肾炎(HSPN)20例;另选取同期该院健康体检儿童30例作为对照组。对所有受试儿童血清补体C1q、RBP及尿mALB水平进行比较分析;同时对观察组治疗前后血清补体C1q、RBP及尿mALB水平进行比较分析;并对HSPN患儿血清补体C1q、RBP及尿mALB单项检测阳性率及联合检测阳性率进行比较。结果与对照组比较,HSP组及HSPN组血清补体C1q水平均升高,HSPN组与对照组差异有统计学意义(P<0.05),但HSP组与对照组差异无统计学意义(P>0.05);与对照组及HSP组比较,HSPN组血清RBP及尿mALB水平差异均有统计学意义(P<0.05);与对照组比较,HSP组尿mALB水平差异有统计学意义(P<0.05),但血清RBP水平差异无统计学意义(P>0.05)。HSPN患儿血清补体C1q、RBP及尿mALB三者联合检测阳性率明显高于单项检测,差异均有统计学意义(P<0.05)。观察组治疗后血清补体C1q、RBP及尿mALB水平与治疗前比较均下降,但三者水平仍高于对照组,差异均有统计学意义(P<0.05)。结论血清补体C1q、RBP及尿mALB联合检测在儿童HSP早期预示肾损伤中有重要临床指导意义。

The clinical value on the serum level of Complement C1q,RBP and urinary mALB in children of early renal injury with Henoch-Schonlein Purpura

Objective To investigate the clinical significance of serum level of Complement C1q,retinol binding protein(RBP)and urinary micro-albumin(mALB)in children of early renal injury with Henoch-Schonlein Purpura(HSP).Methods A total of 70 cases of children of HSP hospitalized in the hospital from July 2017 to December 2018 were selected as the observation group,including 50 cases of simple type of HSP,20 cases of Henoch-Schonlein Purpura Nephritis(HSPN).Thirty healthy children who underwent health examination in the hospital during the same period were selected as control group.The levels of serum Complement C1q,RBP and urinary mALB of the subjects in three groups were compared and analyzed.At the same time,the levels of serum Complement C1q,RBP and urinary mALB before and after treatment in the observation group were compared and analyzed.The positive rate of serum level of Complement C1q,RBP and urinary mALB individually and combined for the children of HSPN were compared and analyzed.Results Compared with control group,the levels of serum Complement C1q in HSP group and HSPN group were increased,the difference between HSPN group and control group was statistically significant(P<0.05),while the difference between HSP group and control group was not statistically significant(P>0.05).Compared with the control group and HSP group,there were significant differences on the levels of serum RBP and urinary mALB in HSPN group(P<0.05).Compared with the control group,there was significant difference on urinary mALB level in HSP group(P<0.05),but there was no significant difference on serum RBP level(P>0.05).The positive rate of combined detection of serum complement C1q,RBP and urine mALB in children with HSPN was significantly higher than that of single detection,and the difference was statistically significant(P>0.05).After treatment,the levels of serum complement C1q,RBP and urine mALB in the observation group decreased,but the three levels were still higher than those in the control group,and the differences were statistically significant(P>0.05).Conclusion The combined detection of complement C1q,RBP and urinary mALB has important guiding significance for the clinical to forecast renal injury in children with HSP.