1445株铜绿假单胞菌临床感染的耐药性分析

目的对临床分离的1 445株铜绿假单胞菌的来源分布及其耐药情况进行分析,为预防和控制铜绿假单胞菌的感染提供依据。方法对长沙市中心医院2008年1月至2011年8月送检标本中分离的铜绿假单胞菌的标本分布情况和耐药性进行回顾性分析。结果共分离1 445株铜绿假单胞菌,对常用抗生素表现较高的耐药性,对头孢哌酮/舒巴坦、阿米卡星、亚胺培南、哌拉西林/他唑巴坦、庆大霉素、头孢吡肟、美罗培南、妥布霉素耐药率较低,分别为20.42%、21.38%、36.47%、37.16%、36.82%、39.17%、39.52%和22.49%。从铜绿假单胞菌分布的标本类型来看,主要为痰液（78.55%）,其次为脓液、分泌物（8.51%）。结论铜绿假单胞菌易产生多重耐药性,必须加强耐药性监测,为临床提供最新的耐药性资料,以更好地控制铜绿假单胞菌感染,延缓多重耐药性的产生。

Analysis of antibiotic resistance of 1 445 strains of Pseudomonas aeruginosa clinical infection

Objective To analyze the source distribution and the drug resistance of the 1 445 strains of Pseudomonas aeruginosa（PA） isolated from clinic to provide the evidence for the prevention and the controlling of Pseudomonas aeruginosa infection.Methods The sample distribution and the drug resistance of PA isolated from our hospital from Jan.2008 to Aug.2011 were analyzed retrospectively.Results Total 1 445 strains of PA were isolated,and highly resisted to commonly used antibiotics and showed lower resistance to cefoperazone-sulbatam,amikacin,imipenem,piperacillin-tazobactam,gentamicin,cefepime,meropenem and tenebrimycin with the resistance rates of 20.42%,21.38%,36.47%,37.16%,36.82%,39.17%,39.52% and 22.49% respectively.The sample types of PA distribution were mainly sputum from respiratory tract（78.55%）,liquor puris and secretion（8.51%）.Conclusion PA easily produces multi-drug resistance.Therefore,monitoring of drug resistance should be strengthened to provide the update drug resistance information for better controlling PA in clinic and postponing the appearance of multi-drug resistance.