GPS评分与结直肠癌预后的关系

目的探讨结直肠术前格拉斯哥预后评分(GPS)与结直肠癌患者预后的关系。方法收集2009年3月至2014年3月广州市第一人民医院胃肠外科收治且行根治性手术的205例结直肠癌患者临床病理及随访2年后的生存资料,化疗之前检测C-反应蛋白、清蛋白、癌胚抗原(CEA)、血浆纤维蛋白原(FIB)以及外周血中性粒细胞/淋巴细胞计数(NLR),并对检测结果进行统计分析。结果不同CEA、FIB、NLR分组之间以及肿瘤分期组间GPS评分差异有统计学意义(P0.05)。患者术前CEA升高(OR=2.255,95%CI:1.092~4.658),肿瘤分期越高(OR=7.750,95%CI:3.539~16.973),GPS评分越高(OR=2.911,95%CI:1.298~6.529),术后患者死亡或者复发风险越高。结论术前GPS评分是结直肠癌预后的独立危险因素,GPS评分高提示预后不良。

Relationship between Glasgow prognostic score and prognosis of colorectal cancer

Objective To investigate the relationship between preoperative Glasgow prognostic score (GPS ) and prognosis of colorectal cancer .Methods The clinical data of 205 colorectal cancer patients followed up for two years were collected during March 2009 to March 2014 in first people′s hospital of Guangzhou .C‐reactive protein ,albumin ,carcinoembryonic antigen (CEA) , plasma fibrinogen (FIB) and neutrophils/lymphocytes ratio (NLR) had been tested before surgery ,and Logistic regression was per‐formed to identify the relationship between preoperative GPS and prognosis of colorectal cancer .Results GPS in different levels of CEA ,FIB ,NLR and different stages of TNM had statistical significance (P<0 .05) .Patients with higher levels of CEA (OR=2 .255 ,95% CI:1 .092-4 .658) ,higher stage of TNM (OR=7 .750 ,95% CI:3 .539 -16 .973) and higher GPS (OR=2 .911 ,95%CI:1 .298-6 .529) increased the risk of death and recurrence of colorectal cancer .Conclusion The preoperative GPS are independ‐ent risk factor for the prognosis of colorectal cancer .Higher GPS indicate a poor prognosis .