急性缺血性脑卒中Lp-PLA2水平与新TOAST分型关系的探究

目的研究急性缺血性脑卒中患者血清脂蛋白相关磷脂酶A2(Lp-PLA2)的变化,并探讨其与急性缺血性脑卒中新TOAST分型之间的关系。方法选取2014~2015年于河北省人民医院就诊的急性缺血性脑卒中患者159例,同时,选择年龄、性别相匹配健康成年人100例作对照组,检测脑卒中组血清Lp-PLA2水平,分析LpPLA2水平在新TOAST各亚型组的变化及相关性。结果脑卒中组患者血清Lp-PLA2水平高于对照组,差异有统计学意义(P0.05),动脉粥样硬化血栓形成(AT)组血清Lp-PLA2水平最高(P0.05)。Logstic回归分析示Lp-PLA2是AT型缺血性脑卒中的危险因素(OR=4.213,95%CI=2.345~9.865,P0.05)。结论 Lp-PLA2在不同类型缺血性脑卒中人群中血清水平不同,脑卒中AT亚型血清Lp-PLA2水平最高。Lp-PLA2是AT型脑卒中发生的危险因素,血清Lp-PLA2水平可用于评估缺血性脑卒中的患病风险,并有助于判断脑卒中的病因学分型。

Lp-PLA2 level in patients with acute ischemic stroke and its relationship with new-TOAST subtypes

Objective To investigate the changes of serum lipoprotein associated phospholipase A2 in patients with acute ischemic stroke and explore the relationship between Lp‐PLA2 and the new‐TOAST subtype .Methods Totally 159 patients with acute ischemic stroke and 100 healthy persons were selected from the Hebei Provice People′s Hospital from 2014 to 2015 .The concentration changes of serum Lp‐PLA2 were measured and the relation‐ship between Lp‐PLA2 and TOAST subtypes were analyzed .Results Levels of Lp‐PLA2 increased significantly in a‐cute ischemic stroke patients than those in the controls(P<0 .05) and levels of Lp‐PLA2 in AT group was the high‐est(P<0 .05) .Logstic regression analysis showed that Lp‐PLA2 was one of the risk factors for acute ischemic stroke (OR=4 .213 ,95% CI=2 .345 -9 .865 ,P<0 .05) .Conclusion Levels of Lp‐PLA2 varied in different TOAST sub‐types and the level in AT group was the highest .Lp‐PLA2 was the risk factor in AT subtypes .Therefore ,serum Lp‐PLA2 level can be used to assess the risk of acute ischemic stroke and to help to determine the TOAST subtypes .