自体细胞因子诱导杀伤细胞治疗恶性肿瘤致发热、寒战的原因分析及预防

目的探讨自体细胞因子诱导杀伤细胞(CIK细胞)治疗恶性肿瘤致发热寒战的原因及预防措施。方法回顾性分析该院肿瘤科自体CIK细胞治疗恶性肿瘤768例患者的临床资料。结果 768例患者中,发生体温低热,无寒战26例;体温中度发热,无寒战14例;体温高热,伴寒战7例,细菌培养致病菌阳性5例,及时对症治疗与护理后好转。发热发生率6.12%;高热伴寒战发生率0.91%;致病菌阳性发生率0.65%。结论自体CIK细胞治疗恶性肿瘤致发热寒战与多种因素有关,采取相应有效的预防措施,能避免发热寒战的发生。

Analysis on reasons of autologous CIK cells for treating pyrexia and shiver caused by malignant tumor and its prevention

Objective To explore the reasons of autologous cytokine induced killer (CIK ) cells for treating malignant tumor caused pyrexia and shiver and its prevention measures .Methods The clinical data of 768 cancer pa‐tients treated by autologous CIK cells in the oncology department of our hospital were retrospectively analyzed .Re‐sults Among 768 cases ,26 cases developed low pyrexia without shiver ,14 cases of middle pyrexia occurred without shiver ,7 cases of high pyrexia complicating shiver occurred ,5 cases were positive pathogenic bacteria in the bacterial culture and improved by timely symptomatic treatment and nursing .The pyrexia occurrence rate was 6 .12% ;the oc‐currence rate of high pyrexia complicating shiver was 0 .91% ;occurrence rate of pathogenic bacterial positive was 0 .65% .Conclusion Pyrexia and shiver caused by autologous CIK cells treating malignant tumor are related with the multiple factors ,Adopting corresponding effective prevention measures can avoid the occurrence of pyrexia and shiv‐er .