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乙型肝炎血清标志物阳性与HBV前S1抗原的关系
引用本文:白洋.乙型肝炎血清标志物阳性与HBV前S1抗原的关系[J].检验医学与临床,2009,6(15):1250-1251.
作者姓名:白洋
作者单位:陕西省汉江职工医院检验科,陕西汉中,723003
摘    要:目的探讨乙型肝炎(简称乙肝)血清标志物阳性携带者与乙肝病毒(HBV)前S1(PreS1)抗原的关系。方法采用全自动酶联免疫分析仪检测563例HBV携带者乙肝5项血清标志物和PreS1抗原水平。结果在563例HBV携带者中,大三阳乙肝表面抗原(HBsAg)、乙肝e抗原(HBeAg)、乙肝核心抗体(抗-HBc)]阳性281例,其中PreS1抗原阳性63例,阳性率为22.4%;小三阳(HBsAg、抗-HBe、抗-HBc)阳性192例,其中PreS1抗原阳性33例,阳性率为17.2%;HBsAg、抗-HBc阳性90例,其中PreS1抗原阳性8例,阳性率为8.9%,各阳性率间差异有统计学意义χ^2=8.61,P〈0.05)。结论PreS1抗原是HBV感染和复制的标志,为HBV存在和复制较为直接的一种标志物,对临床上判断HBV复制和疾病的预后有重要参考意义。

关 键 词:DNA  病毒  肝炎  乙型  肝炎抗原  乙型  肝炎抗体  乙型  带病原状态  前S1抗原  酶联免疫吸附试验

The relationship between positive serum markers of hepatitis B carriers and HBV Pre S1 antigen
BAI Yang.The relationship between positive serum markers of hepatitis B carriers and HBV Pre S1 antigen[J].Laboratory Medicine and Clinic,2009,6(15):1250-1251.
Authors:BAI Yang
Institution:BAI Yang( Department of Clinic Laboratory of Hanjiang Worker's Hospital, Hanzhong , Shanxi 723003,China)
Abstract:Objective To investigate the relationship between the serum markers of hepatitis carriers with B positive HBV and pre S1 antigen.Methods To detect 563 cases of hepatitis B serum markers and 5 PreS1 antigen by means of ELISA automatic enzyme linked immunosorbent assay analysis.Results In 563 cases of hepatitis B virus carriers,there were 281 cases of hepatitis B "E" antigen(HBeAg) positive(HbsAg,HbeAg,HbcAb),with 63 cases of PreS1 antigen positive,and the positive rate was 22.4%;192 cases of hepatitis B "E" ...
Keywords:DNA  viral  hepatitis B  hepatitis B antigens  hepatitis B antibodies  Carries state  pre S1 antigen  enzyme-linked immunosorbent assay
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