米索前列醇预防产后出血的临床效果评价

目的探讨米索前列醇在预防产后出血的临床疗效。方法将120例孕产妇随机分为对照组与观察组,每组60例。给予对照组患者单独使用缩宫素预防产后出血,给予观察组患者米索前列醇联合缩宫素治疗。比较两组产后2h、24h出血量、产后出血发生率、分娩过程中生命体征变化及不良反应发生率。结果观察组产后2h、24h出血量明显少于对照组(P<0.05);观察组与对照组产后出血率分别为6.7%和21.7%,差异具有统计学意义(P<0.01);两组分娩过程中生命体征变化差异无统计学意义(P>0.05);观察组产后不良反应发生率为5.0%,与对照组(3.3%)相比差异无统计学意义(P>0.05)。结论与单独使用缩宫素相比,米索前列醇联合缩宫素可显著减少孕产妇产后出血量,且不良反应轻微。

Clinical effect evaluation of misoprostol on preventing postpartum hemorrhage

Objective To explore the clinical effect of misoprostol on preventing postpartum hemorrhage. Methods 120 cases of pregnant women were randomly divided into the control group and the observation group with 60 cases in each group. The control group received only oxytocin treatment and the observation group was given mi- soprostol combined with oxytocin for preventing postpartum hemorrhage. The bleeding volume at postpartum 2,24 h,incidence rate of postpartum hemorrhage,changes of vital signs during delivery and incidence rate of adverse reac- tions were compared between the two groups. Results The bleeding volume at postpartum 2,24 h in the observation group was significantly less than that in the control group（P〈0.05）. The postpartum hemorrhage rate in the obser- vation group and the control group were 6.7 % and 21.7 % respectively, showing statistical difference （P 〈0. 01 ）. There were no statistical difference in the vital signs during delivery between the two groups（P〉0.05）. The inci- dence rate of adverse reactions in the observation group and the control group were 5.0% and 3.3% respectively, without statistical difference（P〉0.05）. Conclusion Compared with oxytocin alone,misoprostol combined with oxy- tocin can greatly decrease the postpartum hemorrhage amount with less adverse reactions.