铜绿假单胞菌的分布及耐药性分析

目的了解铜绿假单胞菌(PA)的分布及耐药情况,为临床合理使用抗菌药物提供依据。方法收集解放军第四五四医院2008年1月至2010年1月临床各类标本中分离出(非重复)的PA,采用美国德灵MicroScan autoSCAN4全自动细菌鉴定仪及K-B纸片法进行细菌鉴定与药敏试验。结果分离出164株PA,主要来源于痰液、咽拭子和分泌物,主要发生在呼吸科、重症监护室(ICU)和神经科,其中耐亚胺培南铜绿假单胞菌(IRPA)37株,占22.6%。IRPA与非IRPA对常用抗菌药物的耐药率相比,差异有统计学意义(P0.05)。IRPA对比阿培南的耐药率高达81.1%。结论 PA耐药情况比较严重,耐药机制复杂,有多重耐药性,临床应根据药敏结果合理使用抗菌药物。

Analysis on the status of drug resistance and distribution of pseudomonas aeruginosa

Objective To investigate the status of drug resistance and distribution of pseudomonas aeruginosa（PA）,and to provide the evidence in using antibiatics drugs reasonably in clinic.Methods The PA were isolated from the clinical samples which were collected from January 2008 to January 2010 in our hospital and were identified with MicroScan AutoSCAN4 identification system. The drug sensitivity was detected with the K-B mothod.Results 164 strains of PA were mainly isolated from sputum,throat swabs,and secretion in the Department of Pneumology,ICU,and the Department of Neurology.Among them ,there were 37 IRPA species that accounted for 22.6% of the total . The drug resistance rates of the IRPA were significantly higher than that of the non-IRPA（P0.05）.The IRPA resistance rates to biapenem were 81.1%.Conclusion Because of the severe drug resistance situation and complicated mechanism and multiple-resistance of PA,the reasonable application of antibiotics should be done according to the drug sensitivity experimental results.