中国贵州苗族人群血管功能状态及其影响因素分析

目的 评价贵州省苗族人群在原生态生活环境中的血管功能状态,并分析其影响因素.方法 选择生活在贵州省黔东南州雷山县西江镇苗寨中的244名苗族人作为研究对象,所有受检者均进行肱动脉血压测量及血液生化检查,分别应用血压脉搏测量装置及脉搏波传导速度(PWV)测定装置测定心-踝血管指数(CAVI)和PWV作为评价动脉僵硬度的指标,同时对受试者进行超声检查,评价指标有颈动脉内径、颈动脉斑块、内-中膜厚度(IMT)、肱动脉血流介导的血管舒张功能(FMD).结果 不同性别间BMI、腰臀比、心率、血脂水平、血糖等指标差异无统计学意义,血管功能指标中除FMD外,颈动脉-股动脉PWV(9.50±2.14与8.81±1.69,t=2.074,P=0.006)、颈动脉-桡动脉PWV(11.39±1.74与10.54±1.77,t=3.506,P<0.001)、右侧和左侧CAVI(R-CAVI:8.25±1.35与7.41±1.20,t=4.768,P<0.001;L-CAVI:8.21±1.30与7.41±1.15,t=4.616,P<0.001)、右侧和左侧IMTR-IMT:(0.67±0.12)mm与(O.63±0.13)mm,t=2.503,P=0.012;L-IMT:(0.67±0.11)mm与(O.63±0.14)mm,t=2.337,P:0.018]差异均有统计学意义.结论 苗寨中苗族人群就诊率低,需完善医疗条件;进行系统的血管病变评估有利于发现患者及高危人群.

Evaluation of arterial function in Chinese Miao tribe population and analysis of its influential factors

Objective To explore the arterial function of the Miao nationality people who live in natural circumstance.Methods 244 Miaos were mcmited in our studv.Right blood pressure and biochemistry examination were measured.PWV and CAVI were measured using validated automatic devices and used as indexes of arterial stiffness.Ultrasonic indexes such as carotid diameter,carotid plaque,IMT、flow-mediated dilation(FMD) were measured as well.Results Body mass index,waist-to-hip ratio,heart rates,blood lipid level and glucose had no significant difierence between male and female groups.Arterial function indexes such as C-F PWV(9.50±2.14 vs.8.81±1.69,t=2.074,P=0.006),C-R PWV(11.39±1.74 vs.10.54±1.77,t=3.506,P<0.001),R-CAVI(8.25±1.35 vs.7.41±1.20,t=4.768,P<0.001),L-CAVI(8.21±1.30 vs.7.41±1.15,t=4.616,P<0.001),R-IMT(0.67±O.12 vs.0.63±0.13,t=2.503,P=0.012) and L-IMT(0.67±0.11 vs.0.63±0.14,t=2.337,P=O.018) had significant difference between the two groups.Conclusions The medical condition of the Mians needs to be impmved.It is useful to diagnose patients and hish risk people by systemic arterial function examination.