首页 | 本学科首页   官方微博 | 高级检索  
检索        

双水平无创正压呼吸机治疗阻塞性睡眠呼吸暂停综合征合并脑卒中患者的疗效观察
引用本文:孙逊,桑荣霞,赵军.双水平无创正压呼吸机治疗阻塞性睡眠呼吸暂停综合征合并脑卒中患者的疗效观察[J].中国综合临床,2010,26(7).
作者姓名:孙逊  桑荣霞  赵军
作者单位:1. 白求恩国际和平医院呼吸科,石家庄,050082
2. 河北省石家庄市第一医院消化科
3. 河北省石家庄市第一医院心内科
基金项目:河北省科学技术研究与发展指导计划项目 
摘    要:目的 比较应用双水平无创正压呼吸机(BiPAP)和常规药物疗法治疗阻塞性睡眠呼吸暂停综合征(OSAHS)合并脑卒中患者的疗效.方法 选取OSAHS合并脑卒中患者29例,分为治疗组15例和对照组14例,治疗组除采用降颅压,活血化淤,改善微循环,营养脑细胞等常规药物疗法外,坚持使用无创呼吸机2个月,每天10 h以上,对照组只采用常规药物治疗.结果 治疗组睡眠呼吸暂停低通气指数(AHI)、睡眠时<90%氧饱和度次数治疗前后差值分别为36.8±10.7及105.3 ±17.9,显著高于对照组的20.8±8.1及44.4 ±24.3(t=4.502,7.723;P均<0.01),夜间最低SaO2治疗组治疗前后差值为(-11.7±8.1)%,较对照组(-2.0±8.9)%有显著性提高(t=-3.061,P<0.01);神经功能缺损评分治疗前后的差值治疗组为(16.0 ±2.6)分,显著高于对照组的(10.1±3.6)分(t=5.112,P<0.01),但治疗组和对照组的全血黏度及红细胞聚集指数治疗前后差值比较均无统计学意义(P均>0.05).结论 BiPAP治疗OSAHS合并脑卒中患者在常规药物治疗的基础上能明显改善其睡眠呼吸指标及神经功能缺损评分,较单纯应用药物治疗有更显著的疗效,但短期内血流动力学指标改善不显著.

关 键 词:阻塞性睡眠呼吸暂停低通气综合征  双水平无创正压呼吸机  脑卒中

Observation of the effect of bilevel positive airway pressure on patients with obstructive sleep apnea hypopnea syndrome complicated with stroke
SUN Xun,SANG Rong-xia,ZHAO Jun.Observation of the effect of bilevel positive airway pressure on patients with obstructive sleep apnea hypopnea syndrome complicated with stroke[J].Clinical Medicine of China,2010,26(7).
Authors:SUN Xun  SANG Rong-xia  ZHAO Jun
Abstract:Objective To compare the effect between bilevel positive airway pressure (BiPAP) and routine drugs treatment to patients with obstructive sleep apnea hypopnea syndrome ( OSAHS ) complicated with stroke. Methods Twenty-nine patients with OSAHS complicated with stroke were randomly divided into two groups, 15 cases in the treatment group and 14 cases in the control group. Patients in the treatment group were applied BiPAP and routine drugs including degrading intracranial pressure, promoting blood flow, improving microcirculation. BiPAP were maintained for two months and over 10 hours daily. The control group was executed only routine drugs treatment. Results The difference of apnea hyponea index( AHI) and frequency of below 90% O2 saturation during sleep time between pre-therapy and post treatment was significantly higher in the treatment group(36. 8 ± 10. 7 and 105. 3 ± 17. 9) than in the control group (20. 8 ± 8. 1 and 44. 4 ± 24. 3 ) ( P < 0. 01 ) . The difference of lowest nighttime SaO2 between pre- and post-therapy was significantly higher in the treatment group( - 11. 7 ±8. 1)% than in control group(-2. 0 ± 8. 9) % ( P <0. 01). The difference of neurologic impairment score was significantly higher in the treatment group ( 16. 0 ± 2. 6) than in the control group ( 10. 1 ± 3. 6) ( P < 0. 01 ) . As for whole blood viscosity and red blood cell aggregation index,there was no significant difference between pre- and post-therapy(P> 0. 05). Conclusions BiPAP combined with routine drugs can significantly improve sleep anapnea indexs and neurologic impairment scores in patients with OSAHS complicated with stroke than only drug treatment. Blood rheology's indexs could not obtain amelioration in short period.
Keywords:Obstructive sleep apnea hypopnea syndrome  Bilevel positive airway pressure  Stroke
本文献已被 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号