血清尿酸水平与代谢综合征的相关性研究

目的 探讨血清尿酸水平与代谢综合征(MS)及组成MS的因素肥胖、血脂异常、血糖异常、高血压之间的相关性.方法 选择病历资料完整的住院病例654例,年龄30～90岁,中位年龄65岁.代谢综合征的诊断采纳国内标准.检测血清尿酸(SUA)水平及其他相关生化指标.采用Excel软件建立数据库,运用SPSS11.0版软件进行单因素分析、逐步回归分析.结果 超重、空腹血糖(FBG)过高、高TG、高HDL-C增高及高血压(EH)患者的SUA水平均高于非超重、FBG正常、TG正常、HDL-C低及非EH患者(270.52±81.63)μmol/L比(226.61±67.42)μmol/L,t=-7.387,P=0.000;(265.71±73.50)μmol/L比(235.03±75.00)μmol/L,t=-4.459,P=0.000;(262.80±74.44)μmol/L比(235.82±75.04)μmol/L,t=-3.927,P=0.000;(243.97±76.33)μmol/L比(212.78±57.60)μmol/L,t=-2.412,P=0.016;(282.87±64.79)μmol/L比(180.22±41.60)μmol/L,t=22.586,P=0.000].在654例患者中,MS患者107例、非MS患者547例,MS患者的SUA水平高于非MS患者(301.22±68.55)μmol/L比(230.72±71.63)μmol/L,t=9.376,P=0.000].经逐步回归分析提示:收缩压(SBP)、舒张压(DBP)、体重指数(BMI)、TG、HDL-C、FBG均与SUA水平呈正相关(t值分别为3.409、13.401、6.979、2.943、3.514、4.706;P值分别为0.000、0.001、0.000、0.003、0.000、0.000).结论 MS患者的SUA水平高于非MS患者.SUA 水平与组成MS的因素之间呈正相关.

Study on correlation between the level of serum uric acid and metabolic syndrome

Objective To explore the correlation between the level of serum uric acid and metabolic syndrome and associated factors including overweight,abnormality of blood glucose,blood lipid,and hypertension.Methods 654 cases of complete medical records,aging from 30-90with median age of 65 ,were completed were selected,Data base was established by using Excell software,meanwhile,single factor analysis and stepwise regression analysis were performed using SPSS 11.0 software package.Results The levels of serum uric acid of patients with overweight,high fasting blood glucose (FBG),hypertriglyceride (TG),high-density lipid cholesterol (HDL-C)and essential hypertension (EH)were higher than that of patients without overweight,normal fasting blood glucose,normal triglyceride,low high-density lipid cholesterol and without hypertension,respectively respectively,(270.52 ±81.63 )μmol/L vs.(226.61 ± 67.42)μmol/L,t=-7.387,P=0.000;(265.71±73.50)μmol/Lvs.(235.03 ±75.00)μmol/L,t=-4.459,P=0.000;(262.80 ±74.45 )μmol/L vs.( 235.82±75.04)μmol/L,t=-3.927,P=0.000;(243.97 ±76.33)μmol/L vs.(212.78±57.60)μmol/L,t=-2.412,P=0.016;(282.87±64.79)μmol/L vs.( 180.22±41.60)μmol/L,t=22.59,P=0.000 ].The patients with metabolic syndrome (n=107)and the patients without metabolic syndrome (n=547)were included in our study.The level of serum uric acid of patients with metabolic syndrome was higher than that of patients without metabolic syndrome (301.22±68.55 )μmol/L vs.(230.72±71.63)μmol/L,t=9.376,P=0.000].Stepwise regression analysis showed that there was positive correlation between systolic blood pressure (SBP),diastolic blood pressure (DBP),the body mass index (BMI),triglyceride (TG),high-density lipid cholesterol (HDL-C),fasting blood glucose (FBG)and the level of serum uric acid,respectively (t=3.409,13.401,6.979,2.943,3.514,4.706 respectively;P=0.000,0.001,0.000,0.003,0.000,0.000 respectively).Conclusion The level of serum uric acid in patients with metabolic syndrome is higher than those without metabolic syndrome.There is positive correlation between the level of serum uric acid and associated factors of metabolic syndrome including overweight,abnormality of blood glucose and blood lipid,and hypertension.