环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产可行性分析

目的:观察环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产的临床疗效。方法:将2017年2月~2019年7月收治的60例原因不明复发性流产患者分为治疗组、对照组各30例,治疗组采用环孢素联合低分子量肝素钙及寿胎丸加减治疗,对照组采用低分子量肝素钙联合寿胎丸加减治疗,两组疗程均为发现怀孕起至孕12周。观察比较两组临床疗效,治疗前后临床症状积分、CD4⁺/CD8⁺值,人绒毛膜促性腺激素水平和妊娠结局。结果:治疗组总有效率为90.00%,高于对照组的70.00%,差异有统计学意义,P<0.05;治疗后,治疗组与对照组中医临床症状总积分值与治疗前相比较,均有明显下降,治疗组总积分值低于对照组,两组比较有显著性差异,P<0.05;两组CD4⁺/CD8⁺值、人绒毛膜促性腺激素水平、妊娠成功率治疗后较治疗前均有改善,且治疗组改善程度优于对照组,两组比较有显著性差异,P<0.05。结论:环孢素联合低分子量肝素钙及寿胎丸加减治疗原因不明复发性流产有较好的临床疗效。

Feasibility Analysis of Cyclosporine with Combined Low-molecular Weight Heparin Calcium and "Jiajian Shoutai Pilula"in the Treatment of Unexplained Recurrent Spontaneous Abortion

Objective:To observe the clinical efficacy of cyclosporine combined with low-molecular weight heparin calcium and"Jiajian Shoutai pilula"in the treatment of unexplained recurrent spontaneous abortion.Methods:From February 2017 to July 2019,60 admitted patients with unexplained recurrent spontaneous abortion were divided into the treatment group and the control group,with 30 cases in each group.The treatment group was treated with cyclosporine combined with low-molecular weight heparin calcium and"Jiajian Shoutai pilula",while the control group was treated with low-molecular weight heparin calcium combined with"Jiajian Shoutai pilula".The course of treatment in both groups were from the discovery of pregnancy to the 12th week of pregnancy.Observed and compared the clinical efficacy,clinical symptom scores before and after treatment,chorionic gonadotropin level and pregnancy outcome of the two groups.Results:The total effective rate of the treatment group was 90.00,higher than 70.00 of the control group,the difference was statistically significant,P<0.05;after treatment,the total scores of TCM clinical symptoms in the treatment group and the control group were significantly lower than those before treatment,and the total integral value of the treatment group was lower than that of the control group,there was a significant difference between the two groups,P<0.05;the immune cells,levels and pregnancy success rate of the two groups were improved after treatment,and the improvement degree of the treatment group was better than that of the control group,there was a significant difference between the two groups,P<0.05.Conclusion:Cyclosporine combined with low-molecular weight heparin calcium and"Jiajian Shoutai pilula"has good clinical effect in the treatment of unexplained recurrent spontaneous abortion.