首页 | 本学科首页   官方微博 | 高级检索  
检索        

三氧化二砷联合全反式维甲酸治疗急性早幼粒细胞白血病的初步观察
引用本文:赵耀中,李洪强,李大鹏,李睿,齐军元,万长春,周春林,王志强,钱林生.三氧化二砷联合全反式维甲酸治疗急性早幼粒细胞白血病的初步观察[J].中华血液学杂志,2003,24(1):32-34.
作者姓名:赵耀中  李洪强  李大鹏  李睿  齐军元  万长春  周春林  王志强  钱林生
作者单位:300020,天津,中国医学科学院、中国协和医科大学血液学研究所、血液病医院
摘    要:目的 观察三氧化二砷 (As2 O3 )联合全反式维甲酸 (ATRA)治疗急性早幼粒细胞白血病(APL)的疗效和不良反应。方法 As2 O3 联合ATRA治疗初治和复发APL患者 2 0例 (可评价的患者 18例 )。治疗方法如下 :As2 O3 (0 .1%溶液 ) 10ml加入 5 0g L葡萄糖溶液 5 0 0ml静脉点滴 ,持续 4~ 6h ,1次 d ;ATRA 2 5mg·m- 2 ·d- 1 ,分 2~ 3次服用。结果  17例患者获得完全缓解 (CR) ,CR率 94.4%。 14例初治患者均获得CR ,4例复发患者中 3例取得CR。均在 30d内达CR。没有发现明显的不良反应。结论 ATRA联合As2 O3 治疗APL患者不仅能获得好的疗效 ,而且能缩短达CR的时间。

关 键 词:三氧化二砷  全反式维甲酸  治疗  急性早幼粒细胞白血病
修稿时间:2002年1月8日

Preliminary observation of the combination of arsenic trioxide and all-trans retinoic acid for the treatment of acute promyelocytic leukemia
ZHAO Yao-zhong,LI Hong-qiang,LI Da-peng,LI Rui,QI Jun-yuan,WAN Chang-chun,ZHOU Chun-lin,WANG Zhi-qiang,QIAN Lin-sheng.Preliminary observation of the combination of arsenic trioxide and all-trans retinoic acid for the treatment of acute promyelocytic leukemia[J].Chinese Journal of Hematology,2003,24(1):32-34.
Authors:ZHAO Yao-zhong  LI Hong-qiang  LI Da-peng  LI Rui  QI Jun-yuan  WAN Chang-chun  ZHOU Chun-lin  WANG Zhi-qiang  QIAN Lin-sheng
Institution:Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020, China.
Abstract:Objective To observe the efficacy and side effect of the all-trans retinoic acid (ATRA) and arsenic trioxide(As 2O 3) combination in acute promyelocytic leukemia (APL). Methods Twenty APL patients were treated with the ATRA and As 2O 3 combination, and 18 of them could be evaluated. The treatment protocol was as following: 10 mg As 2O 3(0.1% solution)in 500 ml 50 g/L glucose solution for intravenous drip over 4 to 6 hours once a day, ATRA was given 25 mg/m 2 every day. Results Seventeen of the 18 patients achieved complete remission (CR), the CR rate was 94.4%. All 14 newly diagnosed patients and 3 of 4 relapsed patients achieved CR. No significant side effect was observed. Conclusion The As 2O 3 and ATRA in the treatment of APL can obtain a higher CR rate and a shorter duration for achieving CR.
Keywords:Retinoic acid  Arsenic trioxide  Leukemia  promyelocytic  acute  Curative effect  Side effect
本文献已被 CNKI 万方数据 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号