急性髓细胞白血病淋系分化抗原表达及临床意义

为了探讨淋系分化抗原在急性髓细胞白血病(AML)的表达及其临床意义，采用淋系和髓系单克隆抗体，用间接免疫荧光法对62例原发性AML进行免疫表型分析。结果表明：11例除表达髓系抗原外尚有淋系抗原表达(Ly^ AML)。Ly^ AML初诊时肝脾结肿及血像特点与Ly^ AML组无显著差异，用标准诱导化疗仅有1例获长期缓解。结论：Ly^ AML对常规诱导缓解方案不敏感，选择兼顾ALL ANL的方案可望提高治疗效果：Ly^ AML患者长期生存率低可能与CD34^ 高表达有关。

Expression and Clinical Significance of Lymphoid Differentiation Antigens in Acute Myeloid Leukemia

The present study was aimed to elucidate the expression features of lymphoid differentiation antigens and thier clinical implications in acute myeloid leukemia (AML). Immunophenotypes were examined by indirect immunofluorescence method with monoclonal antibodies (McAb) in 62 patients with AML. The results showed that 11 cases of AML were found to express lymphoid differentiation antigen Ly AML in addition to myeloid antigen expression. There was no significant difference in clinical manifestation and blood test between the groups of Ly AML and Ly-AML when they were newly diagnosed. Only one case gained long-term remission using standard chemotherapy. It is concluded that Ly AML cells seem to be not sensitive to convensional chemotherapy,however,a treatment protocol for both ALL and AML can improve the curative effects. The overexpression of CD34 may be responsible for the relatively low level of long term survival rate in Ly AML patients.