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| 急性髓系白血病细胞CD34+抗原表达及与预后的关系 | |
| 引用本文： | 李玲,王蕊,钟笛,温丙昭,迪丽娜孜·阿不来提,蔺志强,贾明,郝建萍,陈瑢,郭新红,王蕾.急性髓系白血病细胞CD34+抗原表达及与预后的关系[J].中国实验血液学杂志,2005,13(5):812-814. |
| 作者姓名： | 李玲 王蕊 钟笛 温丙昭 迪丽娜孜·阿不来提 蔺志强 贾明 郝建萍 陈瑢 郭新红 王蕾 |
| 作者单位： | 1. 新疆医科大学第一附属医院血液科、新疆血液病研究所,乌鲁木齐,830054 2. 上海市杨浦区中心医院内科,上海,200090 3. 新疆富蕴县人民医院检验科,富蕴,836100 4. 兰州军区乌鲁木齐总医院血液科,乌鲁木齐,830000 |
| 基金项目： | 新疆维吾尔自治区科技厅自然科学基金资助,编号200121102 |
| 摘 要： | 为了检测初治急性髓系白血病（AML）细胞CD34^＋抗原的表达,并分析其与预后的关系,应用间接免疫荧光法检测了238例AML患者.结果表明：238例AML中CD34阳性表达者有92例,占38.7%.除M3无CD34阳性表达外,CD34^＋表达与FAB亚型M0、M1有关;CD34^＋组完全缓解率为32%,明显低于CD34^-纽的61%;除淋系抗原CD7在CD34^＋组表达明显增高外,其它淋系抗原表达在两组间无差异（P＜0.05）.结论：有CD34^＋表达的AML患者预后差、CR率低,检测CD34表达对判断AML疗效有一定价值. |
| 关 键 词： | 急性髓系白血病 CD34抗原 白血病预后 |
| 文章编号： | 1009-2137（2005）05-0812-03 |
| 收稿时间： | 2004-08-30 |
| 修稿时间： | 2005-04-11 |
CD34 + Antigen Expression Relating to Prognosis in Acute Myeloid Leukemia |
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| LI Ling,WANG Rui,ZHONG Di,WEN Bin-Zao,Dilinazi · ABULAITI,LIN Zhi-Qiang,JIA Ming,HAO Jian-Ping,CHEN Rong,GUO Xin-Hong,WANG Lei.CD34 + Antigen Expression Relating to Prognosis in Acute Myeloid Leukemia[J].Journal of Experimental Hematology,2005,13(5):812-814. | |
| Authors: | LI Ling WANG Rui ZHONG Di WEN Bin-Zao Dilinazi · ABULAITI LIN Zhi-Qiang JIA Ming HAO Jian-Ping CHEN Rong GUO Xin-Hong WANG Lei |
| Institution: | Department of Hematology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China. |
| Abstract: | To explore CD34~ antigen expression in new diagnosed acute myeloid leukemia (AML) and analyze the prognosis for CD34~ AML patients, the expression of antigen CD34 in 238 AML patients was detected by indirect immunofluorescence assay. The results showed that CD34 in 92 out of the 238 patients (38.7%) were positive, there was relationship between the CD34~ expression and FAB subtypes (M_0, M_1), and no CD34~ expression was observed in M_3 subtyes. The complete remission rate of CD34~ AML patients was 32%, which was lower than that of CD34~- AML(61%). The lymphoid-associated antigen (CD7) was significantly increased in CD34~ AML patients, compared with CD34~- patients (P<0.05). It is concluded that CD34~ AML patients show poor prognosis and lower CR rate. The detection of CD34 expression is of some value in predicting prognosis in AML. |
| Keywords: | acute myeloid luekemia CD34 antigen leukemic prognosis |
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