| 骨髓基质细胞在急性淋巴细胞白血病中作用的研究进展 |
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| 引用本文： | 亢俊楠,陈泽慧,田晨.骨髓基质细胞在急性淋巴细胞白血病中作用的研究进展[J].中国实验血液学杂志,2022(1). |
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| 作者姓名： | 亢俊楠 陈泽慧 田晨 |
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| 作者单位： | 天津医科大学肿瘤医院血液科 |
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| 基金项目： | 国家自然科学基金(81670104)。 |
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| 摘 要： | 急性淋巴细胞白血病(ALL)是一种常见的血液系统恶性肿瘤,其复发及耐药与骨髓微环境有很大程度的关联。骨髓基质细胞(BMSC)作为骨髓微环境的重要组成部分,其与白血病细胞间的相互作用不容忽视。BMSC主要通过分泌细胞因子或细胞外基质蛋白,参与并调节着与ALL细胞增殖或凋亡相关的信号通路,从而影响ALL细胞的生存。为此,本文归纳总结了骨髓基质细胞与ALL细胞相互作用的几条信号通路,综述两者间相互作用的研究进展。
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| 关 键 词： | 骨髓基质细胞 急性淋巴细胞白血病 增殖 凋亡 耐药 |
Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia ——Review |
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| KANG Jun-Nan,CHEN Ze-Hui,TIAN Chen.Research Advances on the Role of Bone Marrow Stromal Cell in Acute Lymphoblastic Leukemia ——Review[J].Journal of Experimental Hematology,2022(1). |
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| Authors: | KANG Jun-Nan CHEN Ze-Hui TIAN Chen |
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| Institution: | (Department of Hematology,Tianjin Medical University Cancer Institute and Hospital,National Clinical Research Center for Cancer,Key Laboratory of Cancer Prevention and Therapy,Tianjin 300060,China) |
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| Abstract: | Acute lymphoblastic leukemia(ALL) is a kind of the most common hematopoietic malignancy,its recurrence and drug resistance are closely related to the bone marrow microenvironment.Bone marrow stromal cell(BMSC) is an important part of the bone marrow microenvironment and their interaction with leukemia cells cannot be ignored.BMSC participates in and regulate signaling pathways related to proliferation or apoptosis of ALL cells by secretes cytokines or extracellular matrix proteins,thus affecting the survival of ALL cells.In this review,the research advance of several signaling pathways of the interaction between BMSC and ALL cells was summarized briefly. |
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| Keywords: | bone marrow stromal cell acute lymphoblastic leukemia proliferation apoptosis drug resistance |
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