| 脑源性神经营养因子对改善东莨菪碱致学习记忆障碍的实验研究 |
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| 引用本文： | 陈蓉,高顺生,饶颖竹.脑源性神经营养因子对改善东莨菪碱致学习记忆障碍的实验研究[J].中国康复医学杂志,1999,14(4):159-161. |
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| 作者姓名： | 陈蓉 高顺生 饶颖竹 |
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| 作者单位： | 广东省湛江师范学院生物系(陈蓉)，广东省湛江师范学院体育系(高顺生)，广东省湛江市临床医学研究所(饶颖竹) |
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| 基金项目： | 广东省湛江师范学院青年教师重点科研项目 |
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| 摘 要： | 目的：探讨脑源性神经营养因子对中枢神经系统高级机能活动的作用机理，为临床应用脑源性神经营养因子治疗学习记忆障碍疾病提供实验依据。方法：以小鼠为实验对象，采用学习记忆行为训练和生化测定的方法，观察脑源性神经营养因子对东莨菪碱致学习记忆障碍、海马脑区蛋白质含量的影响。结果：脑源性神经营养因子能显著地改善东莨菪碱所致的学习记忆障碍，使东莨菪碱实验小鼠海马脑区的蛋白质含量显著增加。结论：脑源性神经营养因子对东莨菪碱所致的小鼠学习记忆障碍的改善与康复均具有明显作用。
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| 关 键 词： | 脑源性神经营养因子 东莨菪碱 学习记忆障碍 |
| 修稿时间： | 1999-03-18 |
Effects of brain-derived
neurotrophic factor on scopolamine-induced memory dysfunction rats |
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| /CHEN Rong,GAO Shunsheng,RAO Yingzhu Dept. of Biology,Zhanjiang Normal
College,Zhanjiang.Effects of brain-derived
neurotrophic factor on scopolamine-induced memory dysfunction rats[J].China Journal of Rehabilitation Medicine,1999,14(4):159-161. |
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| Authors: | /CHEN Rong GAO Shunsheng RAO Yingzhu Dept of Biology Zhanjiang Normal
College Zhanjiang |
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| Institution: | /CHEN Rong,GAO Shunsheng,RAO Yingzhu Dept. of Biology,Zhanjiang Normal
College,Zhanjiang,524048 |
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| Abstract: | Objective: To study the effects of brainderived
neurotrophic factor(BDNF) on the higher nervous activities of central nervous system,and
provide the experimental evidence for the therapeutic possibility of BDNF. Method:
Learningbehavioral training and biochemistry determination were employed.The number of
learning trial( NT of learning) and the rate of right memory response(RR of memory,%,)
were investigated, and the content of protein in hippocampus were determinated. Result
:BDNF prevented the memory dysfunction induced by Scopolamine (P<0.05); The content
of brain protein in hippocampus were increased by BDNF in rats of Scopgroup (P<0.05).
Conclusion:BDNF had effects on improvement of scopolamine induced memory dysfunction. |
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| Keywords: | Brainderived neurotrophic factor Scopolamine Learning and memory dysfunction |
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