运动训练对糖尿病大鼠尾神经传导速度的影响

目的：探讨运动训练对糖尿病大鼠尾神经传导速度（CNCV）的影响。方法：链脲霉素（STZ，55mg/kg）诱导的21只糖尿病大鼠随机平均分配到糖尿病运动8周组（A）、糖尿病运动4周组（B）和糖尿病对照组（C），实验结束时17只糖尿病大鼠存活，其中A组6只、B组6只和C组5只；12只正常血糖大鼠随机分为正常运动8周组（D，n=6）和正常对照组（E，n=6）。运动组大鼠游泳60min/d，5d/周。实验过程中分别于基线、第4周、第8周时测定大鼠血糖、体重和CNCV。结果：糖尿病大鼠基线时血糖显著高于正常血糖大鼠

The effect of exercises training on caudal nerve conduction velocity in diabetic rats

Objective: To explore the effect of exercises on caudal nerve conduction velocity(CNCV) in streptozotocin-induced diabetic rats. Method: Twenty-one diabetic rats induced by streptozotocin(STZ, 55mg/kg) were randomly divided into diabetic group A with exercises for 8 weeks, diabetic group B with exercises for 4 weeks and diabetic control group C without exercises. Seventeen diabetic rats survived at the end of experiment, which were distributed respectively in group A(n=6), group B(n=6) and group C(n=5). Twelve SD rats with euglycemia were randomly divided into normal exercises 8 weeks group D(n=6) and normal control group E(n=6). The exercises rats were forced to swim 60min/d with 5d/week. Body weights, blood glucose and CNCV in all rats were evaluated at the points of baseline, the 4th week and 8th week. Result: Blood glucose in diabetic rats were higher than that in rats with euglycemia (P<0.05). Blood glucose in group A decreased significantly after 8 weeks exercises in comparison with baseline (P<0.05). The CNCV were significantly lower in all diabetic groups than that in groups with euglycemia and were significantly higher in group A than those in groups B and C at the 4th week. The CNCV in groups A and B increased significantly beyond baseline(P<0.05) and to normal level as the groups with euglycemia at the 8th week. The CNCV in group C at the 8th week decreased significantly in comparison with baseline (P<0.05). The CNCV in groups D and E at the 8th week increased significantly in comparison with baseline. Conclusion: Exercises training may prevent and treat the diabetic neuropathy.