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Fipronil-Induced Biochemical Alterations During Oral Subacute Toxicity in Buffalo Calves
Authors:Ajay Kumar Ola  Harpal Singh Sandhu  Bibhuti Ranjan  Vinod Kumar Dumka
Institution:1. Department of Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, 141004, India
Abstract:In the present investigation, detailed oral subacute toxicity study of fipronil, a phenylpyrazole insecticide, was undertaken in male buffalo calves. In oral subacute toxicity study, fipronil was administrated to male buffalo calves at repeated oral dose of 0.5 mg kg?1 day?1 for 21 consecutive days. Fipronil produced varying degree of mild to moderate toxic signs in buffalo calves. Fipronil produced toxic signs of salivation, lachrymal discharge, dullness, depression, decreased body weight gain, alopecia and sunken eyes. All the fipronil-exposed animals recovered within 7 days after insecticidal treatment was stopped. Repeated oral administration of fipronil at the dose rate of 0.5 mg kg?1 day?1 for 21 consecutive days produced significant elevation of whole blood cholinesterase to the extent of 45.17 %. Fipronil on repeated oral administration produced significant increase in the plasma levels of lactate dehydrogenase (7.08 %), aspartate aminotransferase (43.55 %) and acid phosphatase (11.647), but no significant effect on the plasma levels of alanine aminotransferase and alkaline phosphatase in male buffalo calves. Subacute oral administration of fipronil elevated the levels of gamma-glutamyl transferase (25.53 %), total plasma proteins (20.59 %) and blood glucose (40.75 %). However, no significant alteration in the levels of blood urea nitrogen, plasma creatinine and cholesterol was seen following daily oral administration of fipronil in the buffalo calves.
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