醒脑静注射液治疗急性酒精中毒的系统评价

目的评价醒脑静注射液治疗急性酒精中毒的疗效。方法计算机检索MEDLINE（1989～2008年）、中国期刊全文数据库（1991～2008年）、维普资讯-中文期刊数据库（1991～2008年）、万方数字化期刊群（1991～2008年）、中国生物医学文献光盘数据库（1991～2008年）及The Cochrane Library（2008年第4期）,收集醒脑静注射液治疗急性酒精中毒的随机对照试验,对纳入研究进行质量评价后,采用RevMan4.2.2软件进行Meta分析。结果共纳入27篇中文文献,均为低质量文献。Meta分析结果显示,在治疗急性酒精中毒时,西医常规＋醒脑静治疗在显效时间和有效时间上明显优于单纯西医常规治疗,其WMD（95%CI）分别为–90.62 min（–121.12,–60.11）和–124.97 min（–183.54,–66.40）;西医常规＋醒脑静治疗急性酒精中毒在显效时间上较西医常规治疗＋纳洛酮略慢,但有效时间与西医常规治疗＋纳洛酮治疗比较,其差异无统计学意义。结论现有研究表明,西医常规＋醒脑静注射液治疗急性酒精中毒疗效优于单纯西医常规治疗;在常规治疗相同的情况下,醒脑静注射液与纳洛酮疗效相似。

Xingnaojing in the Treatment of Acute Alcohol Intoxication:A Systematic Review

Objective To evaluate the effectiveness of Xingnaojing（XNJ）injection in the treatment of acute alcohol intoxication.Methods The Cochrane library（Issue 4,2008）,MEDLINE（1989 to 2008）,WANFANG database（1991 to 2008）,CBM（1991 to 2008）,and CNKI（1991 to 2008）were searched.The quality of included studies was assessed according to the criteria recommended Cochrane Collaboration.Meta-analyses were performed using RevMan 4.2.2 software.Results Twenty seven trials,all published in China were included.The quality of these studies was low.Meta-analyses showed that normal treatment plus XNJ could significantly shorten action time WMD= -90.62 min, 95%CI （-121.12, -60.11）] and effective time WMD=-124.97 min, 95%CI （-183.54, -66.40）]. Normal treatment plus XNJ was similar with normal treatment plus naloxone in action time. No significant differences were observed in effective time between naloxone and XNJ. Condusions It shows that XNJ injection plus western medical therapy is superior to western medical therapy. The curative efficacy of XNJ and Naloxone was similar.