平均血小板体积与动脉性勃起功能障碍的相关性研究

目的评估平均血小板体积(MPV)与动脉性勃起功能障碍(ED)之间的关系。方法选取动脉性ED患者153例,正常对照150例,比较两组年龄、体重、BMI、血小板数量、MPV、血小板分布宽度(PDW)、性腺六项、血脂、白细胞数、血红蛋白等指标,通过Logistic回归分析评价MPV与动脉性ED的相关性。结果两组年龄、体重、BMI、血小板数量,性腺六项、血脂、白细胞、血红蛋白及PDW等之间差异无统计学意义,MPV动脉性ED组明显高于对照组(9.90±0.98)fl vs.(9.14±1.03)fl,P<0.01]。多因素Logistic回归分析结果显示:MPV与动脉性ED发生具有独立相关性(优势比:3.774,95%可信区间:1.435⁹.928;P<0.01)。结论 MPV作为评价血小板活性的指标,在动脉性ED患者中明显升高,是动脉性ED的独立危险因素。

Correlation between mean platelet volume and arterial erectile dysfunction

ObjectiveTo evaluate the relationship between the mean platelet volume （MPV） and arteriogenic erectile dysfunction （ED）. MethodsBiochemical profile and MPV were measured in 153 patients with arteriogenic ED and 150 healthy controls. The diagnosis of ED was based on the findings from detailed sexual history, physical examination, laboratory assessment , and color Doppler ultrasound. Logistic analysis were employed to clarify the relationship between variables and arteriogenic ED. ResultsThe MPV values were statistically significantly higher in arteriogenic ED group than in control group （9.90±0.98）flvs. （9.14±1.03）fl,P〈0.01]. Multiple logistic analysis demonstrated that MPV were independently associated with the occurrence of arteriogenic ED （OR： 3.774,95%CI： 1.435-9.928;P〈0.01）.ConclusionThe MPV was detected to be increased in patients with arteriogenic ED, which is used widely to measure the size of platelets and indicates platelet reactivity, can provide guidance in the investigation of arteriogenic ED pathophysiology and are an independent risk factor for the occurrence of arteriogenic ED.