不同大小聚乙烯醇颗粒在子宫腺肌症介入治疗中的临床疗效

目的评价不同大小聚乙烯醇(PVA)颗粒在子宫腺肌症介入治疗中的临床疗效。方法回顾性分析152例经子宫动脉栓塞术治疗的子宫腺肌症患者,根据PVA颗粒的大小随机分为A(350⁵00μm)、B(500500μm)、B(500⁷10μm)两组,每组病例76例,比较两组病例经子宫动脉栓塞术治疗后临床症状缓解程度及术后不良反应的差异。结果在痛经减轻、子宫体积变化方面两组比较,术后3个月差异有统计学意义(P<0.05),术后6个月两组比较无统计学差异(P>0.05),术后1年两组痛经减轻程度有统计学差异(P<0.05),而子宫体积方面两组比较无统计学差异(P>0.05),1年后两组病例完全缓解率均达到80%以上,无统计学差异,术后不良反应两组比较有统计学差异(P<0.05),A组不良反应更为显著,而两组在月经期及月经量改变、总有效率比较无统计学差异(P>0.05)。结论虽然两组临床效果半年后即达到相似,但A组术后不良反应疼痛更为严重,故从中长期效果及安全性来看,B组似乎更占优势。

Clinical efficacy of different polyvinyl alcohol particle sizes for uterine artery embolization in adenomyosis

Objective To evaluate whether different polyvinyl alcohol（PVA） particle sizes change the clinical outcome of uterine artery embolization（UAE） in adenomyosis. Methods This retrospective analysis study comprised 152 patients with adenomyosis undergoing UAE with PVA particles. In 76 patients in group A, UAE was started with 350-500 pan particles, in 76 patients in group B, UAE was started with 500-710 tun particles, the clinical outcome were evaluated between the two groups. Results At three months, there were statistically significant differences in decrease in size of uterus and the relieve of dysmenorrhea, however, there were no statistically significant differences in those facets, and there were also no statistically significant difference in the clinical outcome between the two groups after 1 year. But in group A adverse reactions after surgery were more serious, and what＇s more, there were also no statistically significant differences between the menstrual period,the menstrual flow and the total effective rate. Conclusions The initial use of PVA particle sizes 350-500 μm is associated with a higher mean pain score after UAE, although the outcome at 6 months is similar compared with the initial use of particle sizes 500-710 pro. Therefore, from the long-term efficacy and safety point of view, group B（500-710 bun） seems to be more dominant.