| 细胞色素P4502E1基因RsaI／PstI位点多态性与中国人食管癌发病风险关系的Meta分析 |
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| 引用本文： | 冷卫东,胡媛媛,王珏,龚恒,牛玉明,曾宪涛.细胞色素P4502E1基因RsaI／PstI位点多态性与中国人食管癌发病风险关系的Meta分析[J].中华临床医师杂志(电子版),2012(8):113-118. |
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| 作者姓名： | 冷卫东 胡媛媛 王珏 龚恒 牛玉明 曾宪涛 |
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| 作者单位： | [1]湖北医药学院附属太和医院口腔医学中心颌面-头颈外科,湖北十堰442000 [2]湖北医药学院附属太和医院病理科,湖北十堰442000 [3]湖北医药学院附属太和医院耳鼻咽喉科,湖北十堰442000 [4]湖北医药学院形态学实验室,湖北十堰442000 |
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| 基金项目： | 湖北医药学院附属太和医院2011年度博士科研启动基金（2011QD01,2011QD05）;湖北医药学院2011年度优秀中青年科技创新团队项目（2011CZX01）
作者单位： （冷卫东、胡嫒嫒、牛玉明、曾宪涛）,病理科（王珏）,耳鼻咽喉科（龚恒）; （王珏）通讯作者：曾宪涛.F~mail：zengxiantao1128@163.oom |
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| 摘 要： | 目的通过Meta分析的方法系统评价细胞色素P45a2El（CYP2EI）基凶RsaI／PsiI位点多态性与中国人食管癌发病风险的相关性。方法检索PubMed、Embase、CBM，CNKI、VIP和WANFANG数据库中1990年1月1日至2011年11月30日有关CYP2E1基冈多态性与食管癌发病风险关系的文献，进行文献筛选、质量评：价和数据提取后，采用RevMan5．1软件进行Meta分析。结果最终纳入18篇病例对照研究共19个试验，其中食管癌患者1663例，对照2603例。Meta分析结果显示CYP2E1基因多态性与食管癌的关联有统计学意义c2vs．c1：OR=0．64，95％Cl=0.50—0．81，JP=O．0003；c2／c2vs．c1／c1：OR=0．70，95％CI=0．56—0．89，P=0。003；c1／c2vs．c1／c1：OR=0．54，95％C，=0．38—0．75，P=0．0003；c2／c2vs，（c1／c1＋c1／c2）：OR=0．73，95％CI=0．58—0．92，P=0．008；（c1／c2＋c2／c2）vs．c1／c1：OR=0．48，95％vs：0．34—0．70，P=0．0001]；汉族的亚组分析结果也显示cYP2E1基因多态性与食管癌的关联有统计学意义c2vs．c1：OR=O．71，95％CI=0．57—0．89，P=0．002；c2／c2vs．c1／c1：OR=0．75，95％CI=0．59—0．95，P=0．02；c1／c2vs．c1／c1：OR=0．62，95％（1，=0．46—0．84。P=0．002；c2／c2vs．（c1／c1＋c1／c2）：OR=0．78，95％CI=0．61～0．99，P=0．04；（c1／c2＋c2／c2）vs．c1／c1：OR=O．56，95％CI=0．40—0.79，P=0．001]。结论对目前相关研究结果的Meta分析佩示CYP2EI基凶多态性与中国人群食管癌发生风险具有相关性，其RsaI／PstI位点的e2等位基阒可能是食管癌的保护或抑制冈素。
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| 关 键 词： | 细胞色素P450 CYP2E1 多态性，单核苷酸 食管肿瘤 危险凶索 Meta分析 |
CYP2E1 Rsa I/Pst I polymorphism contributes to esophageal cancer risk in Chinese populations：A metaanalysis |
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| LENG Wei-dong,HU Yuan-yuan,WANG Jne,GONG Heng,NIU Yu-ming,ZENG Xian-tao.CYP2E1 Rsa I/Pst I polymorphism contributes to esophageal cancer risk in Chinese populations：A metaanalysis[J].Chinese Journal of Clinicians(Electronic Version),2012(8):113-118. |
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| Authors: | LENG Wei-dong HU Yuan-yuan WANG Jne GONG Heng NIU Yu-ming ZENG Xian-tao |
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| Institution: | . Department of Oral and Maxilllofacial-Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China |
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| Abstract: | Objective To evaluate the relation between CYP2E1 Rsa l/Pst I polymorphism and esophageal cancer risk by recta-analysts. Methods A comprehensive search was performed in PubMed, Embase, CBM, CNKI, VIP and WANFANG database to collect the studies which to investigate the relation between CYP2E1 Rsa I/Pst I polymorphism and esophageal cancer r/sk,from January 1,1990 to until November 30,2010. After studies selected, quality assessed, and data extracted, a meta-analysls was performed by using the RevMan 5. 1 software. ResuRs Eighteen case-control studies including nineteen trails involving 1663 cases and 2603 controls were acquired. The pooled OR with 95% CI indicated that CYP2E1 Rsa I/Pst polymorphism was significantly related with esophageal cancer risk c2 vs. cl ：OR =0, 64,95% CI =0. 50-0. 81 ,P =0. 0003 ;c2/c2 vs. cl/cl ：OR =0. 70, 95% CI=0.56-0.89,P=0.003;cl/c2 vs. cl/c1：0R=0.54,95% CI=0.38-0.75,P=0.0003;c2/c2 vs. （cl/cl ＋ cl/c2） ： OR ：= 0. 73,95 % CI = 0, 58-0. 92, P = 0. 008 ; （ cl/c2 ＋ c2/c2） vs. cl/cl ： OR = 0.48,95% CI = 0. 34- 0. 70 ,P = 0. 00C）1 ] and Hart c2 vs. c1 ： OR = 0, 71,95% CI = 0. 57-0. 89, P = 0. 002 ; c2/c2 vs. cl/cl ： OR = 0. 75, 95% C1 =0. 59＇-0. 95 ,P =0.02;cl/c2 vs. cl/cl ：OR =0. 62,95% CI = 0.46-0. 84,P = 0. 002 ;c2/c2 vs. （ cl/cl ＋ el/c2） .OR =0.78,95% CI =0. 61-0.99,P =0. 04; （ cl/c2 ＋ c2/c2）vs, cl/cl ： OR = 0. 56,95% CI =0.40-0. 79, P = 0. 001 ]. Conclusions Based on currently studies, the CYP2E1 Rsa I/Pst I polymorphism is related with esophageal cancer risk,and the c2 allele may be a decreased risk factor for developing esophageal cancer among in Chinese populations. |
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| Keywords: | Cytochrome P-450 CYP2E1 Polymorphism single nucleotide Esophageal neoplasms Risk factor Meta-analysis |
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