体质量和身高与脑胶质瘤发生的相关关系研究

目的探讨体质量和身高与脑胶质瘤发生的相关关系。方法对本院经临床确诊的100例脑胶质瘤患者（胶质瘤组）和100例健康受试者（对照组），通过结构化面试，了解受试者在21岁时的身高和体质量，成年后最低和最高体质量以及受试前5年的体质量，并分析比较其与脑胶质瘤发生的相关性。结果21岁时体质量过低（体质量指数＜ 18.5 kg/m2）与脑胶质瘤的发生风险呈负相关。这种保护相关性在男性和女性中均可观察到，但仅在女性达到统计学意义（OR 0.63；95% CI为0.42~0.80）。成年身高，近期体质量和成年期体质量变化与脑胶质瘤发生无相关性。结论成年早期低体质量与日后脑胶质瘤发生的风险降低相关。

Study on the Relationship of Body Mass and Height with Glioma

Obj ective]To explore the relationship of body mass and height with the occurrence of glioma.Methods]Totally 100 patients confirmed as glioma clinically（glioma group）and 100 healthy subjects（control group）in our hospital were enrolled in the study.The structuralization interview was used to understand body weight and height of the subj ects at the age of 2 1 years old,lowest and highest weight in adulthood and body weight at 5 years before the study.The relationship of body mass and height with the occurrence of glioma was analyzed.Results]Underweight at the age of 21 years old（BMI〈 18.5 kg/m2 ）was inversely associated with the risk of glioma.The protective correlation was observed in both men and women,but reached statistical significance in women only（OR 0.63;95%CI=0.42,0.80）.Adult height,recent body weight and weight change in adulthood were not associated with the risk of glioma.Conclusion]Low body weight in early adult-hood is associated with a reduced risk of glioma later in life.