CXCR4在复发性胶质瘤中的表达及意义

目的]探讨CXCR4作为脑胶质瘤恶性程度分级指标及治疗靶标的意义.方法]采用免疫组化S-P法,检测复发前后人脑胶质瘤组织中CXCR4的表达.结果]CXCR4在10例正常脑组织中未见表达.在31例原发性和复发性胶质瘤组织中,CXCR4阳性率分别为61.2%（19/31）和87.1%（27/31）,两者比较其差异有统计学意义（P〈0.05）.CXCR4阳性表达与人脑胶质瘤的肿块大小、vimentin表达不相关,而与肿瘤的病理分级、Ki-67表达正相关（P〈0.01,P〈0.05）.结论]CXCR4与胶质瘤的恶性程度相关,可能作为胶质瘤恶性程度的分级指标;CXCR4在人脑胶质瘤组织中高表达,尤其在复发后阳性表达率显著增高,针对CXCR4为治疗靶点的脑胶质瘤分子靶向治疗可能是潜在的有力的治疗手段.

Expression of CXCR4 in Recurrent Glioma and Its Significance

Objective] To explore the significance of CXCR4 as the grade rating index of the malignant de-gree and therapy target of glioma. Methods] The expression of CXCR4 in human glioma before and after re-currence were detected by using immunohistochemical S-P method. Results] There was no expression of CX-CR4 in 10 cases of normal brain tissues（0.0% ）. The positive expression of CXCR4 in 31 cases of primary and recurrent glioma tissues were 61. 2%（19/31） and 87. 1%（27/31）, respectively, and there was significant difference. The positive expression of CXCR4 had no correlation with tumor size and the expression of vimen-tin in human glioma, but was positively correlated to pathological grade and the expression of Ki-67. Conclusion]The expression of CXCR4 in human glioma is positively related to pathological grade and the ex- pression of Ki-67, which indicates that CXCR4 may be associated with the malignant degree of glioma and can be used as the grade rating index of glioma. The expression of CXCR4 in human glioma tissues is high. Espe-cially the positive expression of CXCR4 markedly increases after recurrence, CXCR4 as a therapeutic target may be a potential and powerful method of the target treatment of glioma.