美托洛尔联合依普利酮治疗高血压合并心衰52例疗效观察

目的]探讨美托洛尔联合依普利酮治疗高血压合并心衰的临床疗效和安全性.方法]回顾性分析本院收治的104例高血压合并心衰患者的临床资料,根据治疗方法的不同将其分为观察组(常规治疗+美托洛尔联合依普利酮)和对照组(常规治疗+美托洛尔),每组52例.观察两组治疗前后血压、血浆氨基末端脑钠肽前体(N T-proB-NP)水平、6 min步行试验距离(6MWT)、心功能指标以及两组临床疗效和不良反应发生率.结果]观察组患者治疗总有效率为92.31%(48/52),显著高于对照组的67.31%(35/52),差异有统计学意义(P<0.05).治疗后,两组患者的SBP、DBP及血浆NT-proBNP均低于治疗前,6MWT高于治疗前,且观察组SBP、DBP及血浆NT-proBNP、6MWT比对照组改善明显,差异有统计学意义(P<0.05).治疗后,两组患者LVEDD、LVESD低于治疗前,LVEF高于治疗前,NYHA分级情况均优于治疗前,且观察组心功能指标及NYHA分级情况均优于对照组,差异有统计学意义(P>0.05).两组患者治疗期间恶心呕吐、心率减慢、头晕、皮疹、高钾血症、关节疼痛等不良反应发生率比较,差异无统计学意义(11.54%v s 9.62%,P>0.05).结论]美托洛尔联合依普利酮治疗高血压合并心衰的临床疗效较好,可显著降低患者血压,改善患者的心功能,且安全性高,值得临床推广应用.

Metoprolol Combined with Eplidone in the Treatment of 52 Cases of Hypertension with Heart Failure

(bjetive]To investigate the clinical eficacy and safety of metoprolol combined with eplidone in the treat-ment of hypertensive heart failure.Methods]A total of 104 patients with bypertensive heart failure who were treated in our hospital were enrolled in the study.The patients were divided into lwo groups,control group(n=52)and observation group(n=52).View Blood pressure,amino terminal brain natriuretic peptide precursor(NT-proBNP),6min walking test distance(6MWT),cardiac function index,clinical efficacy and adverse reaction rate were observed before and after treatment in two groups.Results]The total efective rate of the observation group was 92.31%(48/52),significantly higher than that of the control group 67.31%(35/52),the difference was statistically significant(P<0.05).After treatment,SBP,DBP and NT-proBNP in plasma of the two groups were lower than before treatment.and 6MWT was higher than hefore treatment.SBP.DBP and NT proBNP,6MWT in plasma of the observation group were significantly improved compared with the control group(P<0.05).After treatment.LVEDd and LVESD of the two groups were lower than before treatment,LVEF was higher than before treatment,NYHA classification was better than before treatment,and the heart function index and NYHA lassification of the observation group were better than that of the control group,the difference was statistically significant(P>0.05).During the treatment of the two groups,the incidence of adverse reactions such as nausea and vomiting,slow heart rate.dizziness,rash.hyperkalemia.joint pain were compared,and the difference was not statistically significant(11.54% vs 9.62%,P>0.05).Conclusion]Metoprolol combined with eplidone has a good clinical effect in the treatment of hypertension combined with heart failure.It can significantly reduce the blood pressure of patients,improve the heart function of patients,and has a high safety.It is worth clinical application.