ARHI和BECN1在乳腺癌组织中的表达及其与乳腺癌临床病理参数的关系

目的]探讨乳腺癌组织中ras同源家族成员I(ARHI)、自噬相关基因Beclin1(BECN1)的表达水平及其与乳腺癌临床病理参数的关系.方法]选取2013年5月至2018年5月在本院确诊的82例乳腺癌患者的癌组织及癌旁正常组织,采用免疫组化法检测两种组织中ARHI、BECN1的表达水平,分析乳腺癌组织中ARHI、BECN1表达与临床病理参数的关系.结果]ARHI、BECN1在乳腺癌组织中的阳性表达率明显低于癌旁正常组织,其差异具有统计学意义(P<0.05);ARHI与BECN1在乳腺癌组织中的表达呈正相关(P<0.05);ARHI表达与乳腺癌患者年龄、临床分期、有无脉管癌栓、月经状态、肿瘤大小、有无肿瘤家族史、有无神经侵犯无明显相关性(P>0.05),但与乳腺癌患者的淋巴结转移情况、组织分化程度显著相关(P<0.05);BECN1表达与乳腺癌患者年龄、肿瘤大小、有无肿瘤家族史、月经状态、有无神经侵犯无明显相关性(P>0.05),但与乳腺癌患者组织分化程度、是否有脉管癌栓、临床分期、淋巴结转移情况显著相关(P<0.05).结论]ARHI、BECN1在乳腺癌组织中均呈低表达,且两者均与乳腺癌患者组织分化程度、淋巴结转移情况显著相关,提示其对乳腺癌预后判断、指导临床治疗有一定价值.

Expression of ARHI and BECN1 in Breast Cancer Tissues and Its Relationship with Clinicopath-ological Parameters of Breast Cancer

Objective]To investigate expression level of aplasia Ras homologue member I(ARHI)and au-tophagy related gene Beclinl(BECN1)in breast cancer tissues and its relationship with clinicopathological parameters of breast cancer.Methods]The cancer tissues and adjacent normal tissues of 82 breast cancer patients were collected in our hospital from May 2013 to May.The immunohistochemical method was used to detect the expression levels of ARHI and BECN1 in two groups.The correlation between ARHI and BECN1 expression in breast cancer and its relationship with clinicopathological parameters were analyzed.Results]The positive expression rates of ARHI and BECN1 in breast cancer tissues were significantly lower than those in normal adjacent tissues(P<0.05).ARHI was positively correlated with the expression of BECN1 in breast cancer tissues(P<0.05).The expression of ARHI was not correlated with age,clinical stage,vascular tumor thrombus,menstrual status,tumor size,family history of tumors,and nerve invasion of breast cancer patients(P>0.05).while it was significantly correlated with lymph node metastasis and tissue differentiation in breast cancer patients(P<0.05).BECN1 expression in patients with breast cancer was not significantly correlated with age,tumor size,family history of tumor,menstrual status,and nerve invasion(P>0.05),while was significantly correlated with degree of tissue differentiation.vascular tumor thrombus,clinical stage and lymph node metastasis(P<0.05).Conclusion]ARHI and BECN1 are lowly expressed in breast cancer tissues,and the two indicators are positively correlated;ARHI expression is correlated with tissue differentiation degree and lymph node metastasis of breast cancer patients.BECN1 expression is correlated with clinical stage,tissue differentiation degree,lymph node metastasis,and vascular thrombus of breast cancer patients.