| 莱姆病螺旋体的转移感染和致病机制 |
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| 引用本文： | 郝琴,万康林,徐建国.莱姆病螺旋体的转移感染和致病机制[J].疾病监测,2011,26(6):475-478. |
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| 作者姓名： | 郝琴 万康林 徐建国 |
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| 作者单位： | 1.中国疾病预防控制中心传染病预防控制所 传染病预防控制国家重点实验室,北京 102206 |
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| 基金项目： | 国家科技重大专项(艾滋病和病毒性肝炎等重大传染病防治专项)课题(No.2008ZX10004-010;No.2009ZX10004-203)~~ |
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| 摘 要： | 本文主要就莱姆病螺旋体从蜱到宿主动物的转移感染以及在宿主体内存活并致病的机制进行了的阐述,包括螺旋体在蜱内定居以及感染宿主动物过程中蛋白的变化及作用;螺旋体在宿主体内致病的各种机制(病原体本身的作用、免疫逃避、细胞因子的作用、自身免疫)。
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| 关 键 词： | 莱姆病螺旋体 转移 致病 机制 |
| 收稿时间： | 2011-03-04 |
Mechanism of infection transmission and pathogenesis of Borrelia burgdorferi |
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| HAO Qin
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WAN Kang-lin
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XU Jian-guo.Mechanism of infection transmission and pathogenesis of Borrelia burgdorferi[J].Disease Surveillance,2011,26(6):475-478. |
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| Authors: | HAO Qin WAN Kang-lin XU Jian-guo |
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| Institution: | 1.Institute for Communicable Disease Prevention and Control, Chinese Center for Disease Control and Prevention, State Key Laboratory for Communicable Disease Prevention and Control, Beijing 102206, China |
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| Abstract: | The paper describes the mechanism of transmission of Borrelia burgdorferi from ticks to host animals and pathogenesis in host animals,including the colonizing of B.burgdorferi in ticks,the change and role of its proteins in infecting host animals and all the pathogenic mechanisms of B.burgdorferi in host animals(self role of pathogen,immune evasion,function of cytokines and autoimmunity). |
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| Keywords: | Borrelia burgdorferi transmission pathogenesis mechanism |
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