低频振幅fMRI评价精神分裂症患者静息状态下脑功能活动

目的 采用低频振幅(ALFF)方法评价精神分裂症患者静息状态下脑功能活动。 方法 对13例符合精神分裂症诊断标准的患者(精神分裂症组)及18名健康志愿者(正常对照组)行静息态脑fMR扫描,精神分裂症患者和正常对照者的ALFF差异用双样本t检验。 结果 与正常对照组相比,精神分裂症组静息状态下右侧胼胝体压部、右侧枕叶、左侧小脑后叶、左侧额上回和左侧楔前叶脑区ALFF增高,差异有统计学意义(P<0.001,未校正);双侧中央后回和左侧楔前叶脑区ALFF降低,差异有统计学意义(P<0.001,未校正)。 结论 精神分裂症患者静息状态下脑功能存在异常,ALFF有助于对精神分裂症患者静息状态脑功能的理解。

Amplitude of low-frequency fluctuation study of resting-state functional MRI in schizophrenia

Objective To evaluate brain activity in resting-state of schizophrenia patients with amplitude of low-frequency fluctuation (ALFF). Methods Thirteen schizophrenia patients and 18 healthy controls underwent functional MR examination in resting-state, and the difference of ALFF between patients and controls was analyzed with two-sample t test. Results Compared with controls, significantly increasing areas of ALFF in resting-state of schizophrenia included right splenium of corpus callosum, right occipital lobe, left posterior lobe of cerebellum, left superior frontal gyrus and left precuneus (P<0.001, uncorrected), and the decreasing areas included bilateral postcentral gyrus and left precuneus (P<0.001, uncorrected). Conclusion The resting-state fMRI study suggests abnormal brain activity of schizophrenia might exist in resting state, and ALFF might contribute to the understanding of schizophrenia patients' brain function in resting state.