| 多普勒超声对依那普利逆转高血压左室肥厚的评价 |
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| 引用本文： | 王纯,许家琍,王晋明,刘昌慧,张庆华,孙友刚,陈孝义,朱天刚.多普勒超声对依那普利逆转高血压左室肥厚的评价[J].中国医学影像技术,1996,12(4):261-263. |
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| 作者姓名： | 王纯 许家琍 王晋明 刘昌慧 张庆华 孙友刚 陈孝义 朱天刚 |
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| 作者单位： | 武汉湖北医科大学附一院心内科 |
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| 摘 要： | 作者应用转换酶抑制剂（ＡＣＥＩ）──依那普利（Ｅｎａｌａｐｒｉｌ）对３０例轻、中度高血压病患者进行治疗。观察８周后发现：①该药能有效控制血压，治疗前后比较收缩压、舒张压均明显下降（Ｐ＜０．００１），而并无心率增快的副作用；②能逆转左室肥厚（ＬＶＨ），减轻左室心肌重量、左室心肌重量指数等指标（Ｐ＜０．００１）；③对左室收缩功能指标如射血分数等没有明显影响（Ｐ＞０．００５）；④能改善左室舒张功能指标，而以ＰＥ／ＰＡ、Ｅｉ／Ａｉ最为显著Ｐ＜０．００１。结果提示，应用依那普利治疗高血压，短时间内（８周）不仅能有效控制血压，且具有一定逆转ＬＶＨ和改善左室舒张功能的作用。
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| 关 键 词： | 多普勒超声，依那普利，高血压，左室肥厚 |
Doppler Echocardiographical Evaluation:Regression of Left Ventricular Hypertrophy in Esseutial Rypertension by Enalapril |
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| Wang Chun,Xu Jiali,Wang Jinming.Doppler Echocardiographical Evaluation:Regression of Left Ventricular Hypertrophy in Esseutial Rypertension by Enalapril[J].Chinese Journal of Medical Imaging Technology,1996,12(4):261-263. |
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| Authors: | Wang Chun Xu Jiali Wang Jinming |
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| Institution: | Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei;Department of Cardiology, the First Affiliated Hospital of Hubei Medical University, Hubei |
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| Abstract: | The objective of the study is that using Doppler echocardiography to evaluate regressive effects of left ventricular hypertrophy (LVH)in essential hypertension by enalapril. Hemodynamic changes in systolic and diastolic accompany LVH was detected with echocardiography and were measured during this study in 30 esssential hypertension patients treated with 10 mg of enalapril daily for 8 weeks. The results showed :1) SBP, DBP were remarkblely decreased (P<0. 001); 2)indices of LVH such as LVM, LVMI were decreased(P<0. 001); 3)no significant changes of indices of left ventricular systolic function such as EF,FS were found (P>0. 05);4)indices of left ventricular diastolic function as so PE,PE/PA,Ei/Ai were obviously changes (P<0. 001). The conclusion revealed :The blood pressure was not only effectively controlled,but also regression of LVH and improvement of left ventricular diastolic function were bound by Enalapril. |
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| Keywords: | Doppler echocardiography Enalapril Hypertension LVH |
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