联合运用静息态及动态功能连接分析探讨杏仁核在网络游戏成瘾中的意义

目的 联合运用静息态功能连接（rsFC）及动态功能连接（dFC）技术分析网络游戏成瘾（IGD）患者杏仁核与其他脑区脑功能连接的改变。方法 对30例IGD患者（IGD组）与30名志愿者（HC组）行头颅fMRI，分析2组间以双侧杏仁核为种子点的脑功能连接差异，及其与IGD严重程度的关系。结果 与HC组比较，IGD组右侧杏仁核与右侧颞下回、右侧颞中回和右侧额中回rsFC增强；与左侧颞下回、左侧颞上回、右侧枕下回和右侧枕上回rsFC减弱；左侧杏仁核与右侧直回及丘脑rsFC减弱。与HC组比较，IGD组左侧杏仁核与右侧颞中回、左侧额内侧回的dFC方差增大，与右侧楔前叶、右侧顶下小叶、右侧后扣带回以及左侧中央后回dFC方差显著减小；右侧杏仁核与右侧额中回dFC方差增大，与右侧颞中回、左额内侧回及旁扣带回、左侧顶下小叶dFC方差减小。左侧杏仁核与右侧直回的rsFC强度与中文网络成瘾量表（CIAS）评分呈负相关；左侧杏仁核与左侧中央后回的dFC方差与CIAS评分呈正相关，左侧杏仁核与右侧顶下小叶的dFC方差与CIAS评分呈负相关。结论 杏仁核参与了IGD的形成和发展，dFC可以作为rsFC的补充，有助于更好地探索IGD形成和发展的神经学机制。

Combination of resting-state and dynamic functional connectivity in evaluation of amygdala in subjects with internet gaming disorder

Objective To explore the altered functional connectivity of the amygdala in adolescents with internet gaming disorder (IGD) using resting-state functional connectivity (rsFC) and dynamic functional connectivity (dFC) analysis. Methods Thirty adolescents with IGD (IGD group) and 30 demographically matched healthy controls (HC group) were recruited. The right and left amygdala were selected as seed regions, the rsFC and dFC between 2 groups were calculated. The regions showing altered connectivity in IGD were adopted as ROIs for correlation analysis. Results Compared to HC group, IGD group had higher rsFC with the right amygdala over the right inferior temporal, middle temporal gyrus, middle frontal gyrus, lower rsFC with the right amygdala over the left inferior temporal, superior temporal and the right inferior occipital gyrus, superior occipital gyrus. The IGD group had lower rsFC with the left amygdala over the right rectal gyrus and thalamus. Compared to HC group, the IGD group showed higher dFC variance with the left amygdala over the right middle temporal and the left media frontal gyrus, and lower dFC variance over the right precuneus, inferior parietal lobe, posterior cingulate and the left postcentral gyrus. The IGD group showed higher dFC variance with the right amygdala over right middle frontal gyrus and lower dFC variance with the right amygdala over the right middle temporal, the left media frontal gyrus and paracingulate cortex, inferior parietal lobe. The rsFC between the left amygdala and right rectal gyrus was negatively correlated with Chinese Internet Addiction Scale (CIAS) scores. The dFC variance between the left amygdala over the left postcentral gyrus was positively correlated with CIAS scores. The dFC variance between the left amygdala and the right inferior parietal lobe were negatively correlated with CIAS scores. Conclusion The amygdala participates in the development of IGD.